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男性脱发与前列腺素D2研究文献的知识发现

已有 4737 次阅读 2012-3-23 10:57 |个人分类:知识发现|系统分类:科研笔记| 知识, 男性, 前列腺素

宾夕法尼亚大学医学院的研究人员在新研究中发现了一条从前未知的生物信号通路在男性脱发中发挥了重要作用。相关研究论文发表在3月21日的《科学转化医学》(Science Translational Medicine)杂志上,作者们在文章中指出一种称为前列腺素D2(PGD2)的脂质复合物抑制了头发的生长。
 
 
Start A-Literature C-Literature B-list Filter Literature
A-query: Prostaglandin D2   前列腺素D2
C-query: Hair Growth  毛发生长
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 14952 and can be accessed from the start page after you leave this session. There are 552 terms on the current B-list (发现这两者研究文献中的基因与遗传学知识概念120个 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms

 
 
job id # 14952 started Thu Mar 22 20:05:23 2012
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: Prostaglandin D2Thu Mar 22 20:05:34 2012

A query = Prostaglandin D2 started Thu Mar 22 20:05:35 2012
A query resulted in 3859 titles
C_query_raw: Prostaglandin D2 Thu Mar 22 20:05:39 2012

C: Prostaglandin D2 3859

A: pubmed_query_A 3859

AC: ( Prostaglandin D2 ) AND ( Prostaglandin D2 ) 3859

C_query_raw: Hair Growth Thu Mar 22 20:05:48 2012

C: Hair Growth 10758

A: pubmed_query_A 3859

AC: ( Prostaglandin D2 ) AND ( Hair Growth ) 1

C_query_raw: Hair Growth Thu Mar 22 20:05:55 2012

C: Hair Growth 10758

A: pubmed_query_A 3859

AC: ( Prostaglandin D2 ) AND ( Hair Growth ) 1

C query = Hair Growth started Thu Mar 22 20:05:56 2012
C query resulted in 10758 titles
A AND C query resulted in 1 titles
5330 B-terms ready on Thu Mar 22 20:07:46 2012

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
552 B-terms left after filter executed Thu Mar 22 20:11:42 2012

B-list on Thu Mar 22 20:14:44 2012
1 vegf
2 akt
3 stat3
4 cox-2
5 smad
6 signal regulated kinase
7 ppar alpha
8 c kit
9 smad2
10 sox9
11 sonic hedgehog
12 map kinase
13 ppar
14 jnk
15 pten
16 chemokine
17 nf kappab
18 kit ligand
19 bdnf
20 n myc
21 estrogen receptor alpha
22 ccaat enhancer binding
23 hepatocyte growth factor
24 retinoic acid receptor
25 phosphatidylinositol 3-kinase
26 defensin
27 mek
28 c ebp
29 transcription factor
30 cd133
31 retinoblastoma protein
32 rankl
33 rxr
34 tgf beta
35 mitf
36 leptin
37 tgf beta1
38 pi3k
39 cyclin dependent kinase
40 neurotrophin
41 estrogen receptor beta
42 fk506
43 c myc
44 cyclin d1
45 bax
46 pparalpha
47 single nucleotide polymorphism
48 cd40
49 nude
50 rac1
51 glutathione s transferase
52 ngf
53 hif-1
54 activin
55 nadph oxidase
56 bcl-2
57 pthrp
58 myc
59 peroxisome
60 kruppel
61 gene promoter
62 kruppel factor
63 caspase
64 matrix metalloproteinase
65 potassium channel
66 cadherin
67 polycystic ovary syndrome
68 cdna
69 b16
70 survivin
71 candidate gene
72 hairless
73 tyrosine kinase
74 il-8
75 gata-3
76 histone deacetylase
77 enhancer
78 bfgf
79 bcl xl
80 erbb
81 aromatase
82 epidermal growth factor
83 e knockout mice
84 gene encoding
85 cytokine
86 ifn gamma
87 cyclin
88 tnf alpha
89 gata3
90 erk
91 chop
92 e cadherin
93 insulin growth factor
94 nf
95 p27
96 promoter activity
97 clusterin
98 estrogen receptor
99 statin
100 ornithine decarboxylase
101 mmp-9
102 mip-2
103 receptor gene
104 rho kinase
105 protein kinase c
106 hedgehog
107 calcitonin gene related
108 tgfbeta
109 gene related peptide
110 egfr
111 kit
112 nf kappa b
113 receptor tyrosine kinase
114 phospholipase d
115 protooncogene
116 p21
117 tenascin c
118 factor gene
119 phospholipase
120 sirt1

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature
AB literature

B-term

BC literature

Prostaglandin D2 vegf Hair Growth
1: PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts. 2007
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2: Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. 2006
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3: Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. 2006
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4: Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1. 2004
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5: Rapid change of glucose concentration promotes mesangial cell proliferation via VEGF: inhibitory effects of thiazolidinedione. 2004
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6: Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1. 2002
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1: The anti-proliferative side effects of AEE788, a tyrosine kinase inhibitor blocking both EGF- and VEGF-receptor, are liver-size-dependent after partial hepatectomy in rats. 2010
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2: Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear. 2009
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3: Fast alterations of vascular endothelial growth factor (VEGF) expression and that of its receptors (Flt-1, Flk-1 and Neuropilin) in the cochlea of guinea pigs after moderate noise exposure. 2007
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4: Vascular endothelial growth factor (VEGF) expression in noise-induced hearing loss. 2006
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5: [Implication of VEGF, steroid hormones and neuropeptides in hair follicle cell responses] 2002
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6: Control of hair growth and follicle size by VEGF-mediated angiogenesis. 2001
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7: Immunohistochemical detection of vascular endothelial growth factor (VEGF) and VEGF receptors Flt-1 and KDR/Flk-1 in the cochlea of guinea pigs. 2001
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8: The role of VEGF and thrombospondins in skin angiogenesis. 2000
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9: Anti-androgens and estrogens: modulators of VEGF expression in cultured hair dermal papilla cells. 1999
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10: Expression of vascular endothelial growth factor (VEGF) in various compartments of the human hair follicle. 1998
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11: [Pilar growth: VEGF and fibroblasts of the follicular papilla] 1998
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12: Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells. 1996
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13: Vascular endothelial cells: targets for studying the activity of hair follicle cell-produced VEGF. 1996
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