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肿瘤干细胞的概念与理论知识发现

已有 3579 次阅读 2011-12-12 14:01 |个人分类:知识发现|系统分类:论文交流| 知识, 干细胞

 
        癌症干细胞(Cancer Stem Cell,CSC),又称癌干细胞、肿瘤干细胞(Tumor Stem Cell,TSC),是指具有干细胞性质的癌细胞,也就是具有“自我复制”(self-renewal)以及“具有多细胞分化”(differentiation)等能力。通常这类的细胞被认为有形成肿瘤,发展成癌症的潜力,特别是随着癌症转移出去后,产生新型癌症的来源。 肿瘤内许多的细胞,该假说只有一群细胞具有永生不死、持续分裂、分化的能力,被称为癌症干细胞。癌症干细胞被认为是造成癌症转移、复发,或是肿瘤对于化疗、放射性疗法产生抗性的原因之一。目前针对这个理论,学者希望研究出针对癌症干细胞的疗法,能够专一性的杀死癌症干细胞,以降低肿瘤产生抗药性或是转移的现象。
 
发现结果
Start A-Literature C-Literature B-list Filter Literature
A-query: Tumor Stem Cell
C-query: stem cell differentiation)
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 9197 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 28486 and can be accessed from the start page after you leave this session. There are 8938 terms on the current B-list (发现4563个肿瘤干细胞的概念与理论知识单元,对相关科研工作有参考意义 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 
 
job id # 28486 started Tue Dec 13 01:18:31 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
28486 Search ARROWSMITH A
A_query_raw: Tumor Stem CellTue Dec 13 01:32:20 2011

A query = Tumor Stem Cell started Tue Dec 13 01:32:21 2011
A query resulted in 31139 titles
28486 Search ARROWSMITH C
C_query_raw: stem cell differentiation) Tue Dec 13 01:32:58 2011

C: stem cell differentiation) 65412

A: pubmed_query_A 31139

AC: ( Tumor Stem Cell ) AND ( stem cell differentiation) ) 9197

C query = stem cell differentiation) started Tue Dec 13 01:33:01 2011
C query resulted in 50000 titles
A AND C query resulted in 9197 titles
35998 B-terms ready on Tue Dec 13 01:38:14 2011

Sem_filter:
Concepts & Ideas
8938 B-terms left after filter executed Tue Dec 13 02:19:19 2011

前300个知识单元

B-list on Tue Dec 13 02:25:55 2011
1 jak stat
2 human neural stem
3 lentiviral vector
4 stat pathway
5 ccaat enhancer binding
6 neural stem cell
7 european group blood
8 group blood marrow
9 nonmyeloablative allogeneic
10 jun n terminal
11 marrow mesenchymal stem
12 mobilization peripheral blood
13 chemotherapy autologous stem
14 cell transplantation multiple
15 non myeloablative allogeneic
16 myeloablative allogeneic
17 zinc finger
18 nodal signaling
19 blood marrow transplantation
20 human mesenchymal stem
21 hematopoietic growth
22 c jun n
23 zinc finger gene
24 derived mesenchymal stem
25 diabetic severe combined
26 homeodomain
27 alternative splicing
28 dose chemotherapy peripheral
29 adult neural stem
30 stat5 activation
31 autologous stem cell
32 prostate stem
33 activation akt
34 chemotherapy autologous peripheral
35 dose chemotherapy autologous
36 n myc
37 nonmyeloablative hematopoietic
38 vascular endothelial growth
39 nonobese diabetic severe
40 beta signaling
41 neural stem
42 limbal stem cell
43 vivo expansion hematopoietic
44 cord blood hematopoietic
45 cord blood transplant
46 transplantation chronic myeloid
47 transducer activator transcription
48 transducer activator
49 signal regulated kinase
50 extracellular signal regulated
51 signal transducer activator
52 nonmyeloablative allogeneic stem
53 myeloablative allogeneic stem
54 hypoxia inducible
55 monocyte derived dendritic
56 hla identical
57 n terminal kinase
58 terminal kinase
59 differentially expressed gene
60 csf mobilized peripheral
61 allogeneic peripheral blood
62 adenoviral vector
63 gene marking
64 side population cell
65 marrow derived mesenchymal
66 akt activation
67 cfu
68 factor beta signaling
69 cell transplantation acute
70 line derived neurotrophic
71 vivo expansion cd34
72 gene transfer hematopoietic
73 transplantation non hodgkin
74 jak stat pathway
75 allogeneic hematopoietic stem
76 cd34 hematopoietic
77 high dose chemotherapy
78 autologous hematopoietic
79 hypoxia inducible factor
80 cell transplantation chronic
81 induced pluripotent
82 nestin expression
83 induced pluripotent stem
84 cell depleted allogeneic
85 retroviral mediated gene
86 cd34 hematopoietic progenitor
87 autologous hematopoietic stem
88 arrest apoptosis
89 polycomb group
90 internal tandem duplication
91 expansion cd34
92 expression vascular endothelial
93 hypoxia inducible factor-1
94 iron responsive element
95 erythroid colony
96 stem cell deficiency
97 derived mesenchymal progenitor
98 retroviral mediated
99 human breast epithelial
100 c ebp
101 effect flt3
102 dose chemotherapy
103 allogeneic blood stem
104 quantitative proteomic
105 allogeneic haematopoietic
106 orphan nuclear
107 expansion human umbilical
108 human limbal epithelial
109 transplantation multiple myeloma
110 chimerism allogeneic
111 adenoviral mediated
112 cd34-positive hematopoietic
113 expression profiling
114 stem cell therapy
115 transfer hematopoietic
116 cell transplantation incidence
117 stat3 activation
118 activation wnt
119 chemotherapy peripheral blood
120 cell transplantation severe
121 cell cfu
122 memory cd8 t
123 caspase activation
124 model parkinson disease
125 high dose melphalan
126 expression nestin
127 inflammatory cytokine
128 neuronal stem cell
129 somatic cell nuclear
130 c myb
131 activation p38
132 csf mobilization
133 therapeutic angiogenesis
134 c ebpalpha
135 transgene expression
136 expression angiopoietin-1
137 cd34-positive cell
138 molecular remission
139 leukemia zinc finger
140 colony forming cell
141 derived mesenchymal
142 stat signaling
143 mobilization granulocyte colony
144 peripheral blood cd34-positive
145 stem cell isolation
146 proliferator activated
147 derived neural stem
148 proliferator activated receptor
149 epidermal stem cell
150 autologous peripheral blood
151 macrophage colony forming
152 human immature dendritic
153 risk myelodysplastic syndrome
154 autologous peripheral
155 progenitor cell cfu
156 progenitor cell mobilization
157 jak stat signaling
158 transplantation lymphoma
159 transduced hematopoietic stem
160 risk myelodysplastic
161 adenovirus vector
162 hematopoietic microenvironment
163 cd34 hematopoietic stem
164 mesenchymal progenitor
165 marrow mesenchymal
166 dose melphalan
167 cell mobilization granulocyte
168 interferon regulatory
169 activation signal transducer
170 leucine zipper
171 hypoxia inducible factor-1alpha
172 transplantation cd34
173 transduced hematopoietic
174 generation dendritic cell
175 hla identical sibling
176 activation extracellular signal
177 flt3 internal tandem
178 autologous blood stem
179 double strand break
180 transfer hematopoietic progenitor
181 iron regulatory
182 chemotherapy autologous
183 extracellular signal
184 real time pcr
185 mixed chimerism
186 chemotherapy stem cell
187 mesenchymal progenitor cell
188 murine hematopoietic progenitor
189 c elegans
190 human granulocyte colony
191 progenitor cell growth
192 retroviral gene transfer
193 mast cell growth
194 stem cell self
195 stem cell senescence
196 human hematopoietic progenitor
197 treatment acute myeloid
198 human hematopoietic stem
199 graft versus leukemia
200 mobilization endothelial
201 mesenchymal stem cell
202 transcriptional regulatory
203 identical sibling
204 mammary stem cell
205 high proliferative potential
206 allogeneic hematopoietic
207 multipotent mesenchymal stromal
208 mesenchymal stem
209 bone marrow mesenchymal
210 chronic myeloproliferative
211 model huntington disease
212 human cd34 hematopoietic
213 epsilon caprolactone
214 activation stat3
215 proliferation apoptosis
216 dose chemotherapy stem
217 regulatory t cell
218 novel stem cell
219 retroviral transduction
220 nonmyeloablative allogeneic hematopoietic
221 cardiac progenitor
222 diffuse large
223 stromal cell line
224 osteoclast formation
225 model alzheimer disease
226 post transplant lymphoproliferative
227 expansion hematopoietic
228 transplantation hematological
229 stem cell expansion
230 cd34-positive
231 low risk myelodysplastic
232 kruppel zinc finger
233 human limbal
234 composite scaffold
235 cell support high
236 expression vascular
237 cell transplantation primary
238 transduction hematopoietic
239 loop binding protein
240 adeno associated viral
241 hemopoietic stem
242 expression analysis
243 effect paclitaxel
244 therapy stem cell
245 expression pluripotent
246 double strand
247 risk acute myeloid
248 bcl-2 expression
249 dose chemotherapy breast
250 derived mesenchymal stromal
251 human mesenchymal stromal
252 hematopoietic rescue
253 zinc finger transcription
254 wb f344
255 cell self renewal
256 stem cell neural
257 expression apoptosis
258 thymic epithelial
259 cord mesenchymal
260 cxcr4 expression
261 umbilical cord mesenchymal
262 manipulation hematopoietic
263 autologous mesenchymal stem
264 progenitor cell isolation
265 acute promyelocytic
266 cultured human mast
267 p27kip1 expression
268 hematopoietic stem progenitor
269 enriched hematopoietic
270 idiopathic pneumonia syndrome
271 epithelial homeostasis
272 associated virus vector
273 hair follicle bulge
274 retroviral transduction human
275 therapeutic neovascularization
276 allogeneic stem cell
277 severe aplastic
278 novo acute myeloid
279 disease allogeneic hematopoietic
280 following allogeneic hematopoietic
281 planar cell polarity
282 allogeneic hematopoietic transplantation
283 gammadelta t
284 epithelial stem cell
285 splice variant
286 transgene expression human
287 cord mesenchymal stem
288 haploidentical transplantation
289 epithelium derived factor
290 renewal hematopoietic
291 autologous mesenchymal
292 chronic gvhd
293 versus myeloma effect
294 reconstitution hematopoietic stem
295 graft versus myeloma
296 cytokine mobilized peripheral
297 expression telomerase
298 epithelial stem
299 cell transplantation high
300 umbilical cord derived



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