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血清素与动物性取向研究的信息分析与基因知识发现

已有 8543 次阅读 2011-3-24 15:35 |个人分类:神经科学|系统分类:论文交流| 性取向, 血清素

血清素与血清神经元可调控哺乳动物性取向
北京大学生命科学学院院长饶毅教授课题组通过研究发现,神经递质五羟色胺(5-HT,又称血清素)在哺乳动物性取向中具有重要作用。
Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice Journal name: Nature Year published: (2011) DOI: doi:10.1038/nature09822 Received 12 August 2010 Accepted 14 January 2011 Published online 23 March 2011
 
相关研究主题(详细分析报告见附件)
5-HT   and  sexual preference
 
 
附件:信息分析报告  sexual preference.docx
 
 
 
Start A-Literature C-Literature B-list Filter Literature
A-query: 5-HT and sexual preference
C-query: brains and male mice
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 19 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 30269 and can be accessed from the start page after you leave this session. There are 190 terms on the current B-list (48 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 
基因知识发现结果
 
job id # 30269 started Thu Mar 24 02:46:27 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
30269 Search ARROWSMITH A
A_query_raw: 5-HT and sexual preferenceThu Mar 24 02:46:44 2011

A query = 5-HT and sexual preference started Thu Mar 24 02:46:45 2011
A query resulted in 861 titles
30269 Search ARROWSMITH C
C_query_raw: brains and male mice Thu Mar 24 02:47:08 2011

C: brains and male mice 43446

A: pubmed_query_A 861

AC: ( 5-HT and sexual preference ) AND ( brains and male mice ) 19

C query = brains and male mice started Thu Mar 24 02:47:10 2011
C query resulted in 43446 titles
A AND C query resulted in 19 titles
3398 B-terms ready on Thu Mar 24 02:51:14 2011

Viewed B-terms Thu Mar 24 02:52:25 2011

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
190 B-terms left after filter executed Thu Mar 24 02:55:43 2011

B-list on Thu Mar 24 02:56:48 2011
1 5-ht1a
2 eralpha
3 5-ht3
4 5-ht2a
5 5-ht2c
6 5-ht2
7 5-ht1b
8 estrogen receptor alpha
9 leptin
10 ssri
11 opiate receptor
12 aromatase
13 lhrh
14 gene schizophrenia
15 c fos
16 transgene
17 dopamine receptor
18 pkc
19 tryptophan hydroxylase gene
20 crh
21 trh
22 estrogen receptor
23 thyrotropin releasing hormone
24 5ht1a
25 hedgehog
26 5-ht
27 monoamine oxidase
28 neuropeptide
29 cpp
30 snp
31 fos
32 drd3
33 tryptophan hydroxylase
34 hydroxylase gene
35 dopa
36 maoa
37 epilepsy
38 msh
39 locomotor activity
40 sch
41 g protein
42 2c
43 transporter
44 1d
45 gaba
46 emotionality
47 adhd
48 als


高相关研究主题实例

5-HT and sexual preference 5-ht3 brains and male mice

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature
AB literature

B-term

BC literature

5-HT and sexual preference 5-ht3 brains and male mice
1: 5-HT3 receptors in the ventromedial nucleus of the hypothalamus and female sexual behavior. 1997
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2: Effects of 5-HT3 agonists on reproductive behaviors in rats. 1994
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3: Effects of chlordiazepoxide, buspirone and the 5-HT3 receptor antagonist, BRL 46470, on the behaviour of oestrous and dioestrous female mice when encountering male partners. 1993
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4: Lack of effects of 5-HT3 antagonists on normal and morphine-attenuated sexual behaviours in female and male rats. 1993
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1: From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics. 2009
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2: Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission. 2009
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3: Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor. 2009
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4: Dopamine neurotransmission is involved in the attenuating effects of 5-HT3 receptor antagonist MDL 72222 on acute methamphetamine-induced locomotor hyperactivity in mice. 2008
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5: Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors. 2005
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6: Orally active benzoxazole derivative as 5-HT3 receptor partial agonist for treatment of diarrhea-predominant irritable bowel syndrome. 2005
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7: Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide. 2005
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8: Benzimidazole derivatives. Part 5: design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands. 2004
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9: Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier. 2002
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10: Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors. 1999
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11: Quinolizidinyl derivatives of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid and 1-homolupinanoyl benzimidazolones as ligands for 5-HT3 and 5-HT4 receptors. 1999
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12: Study of mechanisms of calcitonin analgesia in mice. Involvement of 5-HT3 receptors. 1999
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13: Benzoxazole derivatives as novel 5-HT3 receptor partial agonists in the gut. 1998
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14: Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure. 1997
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15: Synthesis and evaluation of 5-HT3 receptor antagonist [11C]KF17643. 1996
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16: Synthesis and 5-HT3 affinity of new 3-substituted indoles at central nervous system. 1996
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17: Synthesis of 5-HT3 receptor antagonists, [11C]Y-25130 and [11C]YM060. 1995
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18: The pharmacology of VA21B7: an atypical 5-HT3 receptor antagonist with anxiolytic-like properties in animal models. 1995
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19: 5-HT3 receptor antagonism by anpirtoline, a mixed 5-HT1 receptor agonist/5-HT3 receptor antagonist. 1995
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20: Effects of iodoproxyfan, a potent and selective histamine H3 receptor antagonist, on alpha 2 and 5-HT3 receptors. 1995
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21: Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. 1995
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22: The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide facilitates noradrenaline release by blockade of alpha 2-adrenoceptors in the mouse brain cortex. 1994
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23: Effects of 5-HT3 receptor antagonists on binding and function of mouse and human GABAA receptors. 1994
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24: A mechanism of 5-HT3 receptor mediation is involved etiologically in the psychological stress lesion the stomach of the mouse. 1994
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25: Intrathecal 5-methoxy-N,N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors. 1993
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26: SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. 1993
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27: Electrophysiological, biochemical and behavioral evidence for 5-HT2 and 5-HT3 mediated control of dopaminergic function. 1993
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28: Different densities of 5-HT3 receptors are labeled by [3H]quipazine, [3H]GR 65630 and [3H]granisetron. 1993
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29: Behavioural studies on WAY100289, a novel 5-HT3 receptor antagonist, in two animal models of anxiety. 1992
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30: Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA. 1991
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31: The differential activities of R (+)- and S(-)-zacopride as 5-HT3 receptor antagonists. 1990
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32: The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates. 1990
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33: Neuroanatomical sites of action of 5-HT3 receptor agonist and antagonists for alteration of aversive behaviour in the mouse. 1989
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34: Binding of the 5-HT3 ligand, [3H]GR65630, to rat area postrema, vagus nerve and the brains of several species. 1989
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35: Localisation by autoradiography of neuronal 5-HT3 receptors in the mouse CNS. 1988
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