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急性癌症爆炸破坏DNA的研究动态与理论概念知识发现

已有 3537 次阅读 2011-1-10 11:06 |个人分类:知识发现|系统分类:论文交流| DNA, 成因, 染色体, 知识发现, 急性癌症

科学家揭秘“急性癌症”成因：染色体“爆炸”破坏DNA

http://news.sciencenet.cn/htmlnews/2011/1/242576.shtm

英国科学家找到了“急性癌症”的形成原因：细胞内的染色体发生“爆炸”破坏了DNA，从而让人有可能在短时间内患上癌症。

Why some cancers seems to develop in an instant - cells can explode wreaking havoc in DNA

http://www.dailymail.co.uk/health/article-1344740/Why-cancers-develop-instant--cells-explode-wreaking-havoc-DNA.html

The mystery of 'instant cancers' - tumours that seem to appear out of nowhere - has been solved by British scientists.

In some cases, a single apocalyptic ‘explosion’ in a cell can cause as much damage to the DNA as decades of hard living.

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 

Start A-Literature C-Literature B-list Filter Literature
A-query: instant cancers
C-query: DNA damage
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 6 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 13989 and can be accessed from the start page after you leave this session. There are 426 terms on the current B-list (89 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

job id # 13989 started Sun Jan 9 22:35:53 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
13989 Search ARROWSMITH A
A_query_raw: instant cancersSun Jan 9 22:36:11 2011

A query = instant cancers started Sun Jan 9 22:36:11 2011
A query resulted in 212 titles
13989 Search ARROWSMITH C
C_query_raw: DNA damage Sun Jan 9 22:36:41 2011

C: DNA damage 85835

A: pubmed_query_A 212

AC: ( instant cancers ) AND ( DNA damage ) 6

C query = DNA damage started Sun Jan 9 22:36:42 2011
C query resulted in 50000 titles
A AND C query resulted in 6 titles
1344 B-terms ready on Sun Jan 9 22:40:06 2011

Sem_filter:
Concepts & Ideas
426 B-terms left after filter executed Sun Jan 9 22:45:48 2011

B-list on Sun Jan 9 22:46:25 2011
1 non small cell
2 small cell lung
3 cancer xenograft
4 time rt pcr
5 linear quadratic
6 real time rt
7 small cell
8 melanoma progression
9 acute myeloid
10 superficial bladder
11 xenograft
12 chronic lymphocytic
13 treatment arsenic trioxide
14 b cell chronic
15 quantitative real time
16 nci
17 superficial bladder cancer
18 patient colorectal
19 formation lung
20 overexpression
21 intravesical
22 solitary fibrous tumor
23 cell chronic lymphocytic
24 colorectal
25 radiotherapy
26 chemotherapy
27 alteration apoptosis
28 specific cytotoxic t
29 orthotopic model
30 real time
31 surface plasmon
32 cancer therapy
33 estrogen receptor er
34 enhanced ultrasound induced
35 advanced breast cancer
36 myeloid
37 red fluorescent
38 status breast cancer
39 study oxidative
40 diagnosis breast cancer
41 focused ultrasound
42 duplication
43 fractionated radiotherapy
44 rt
45 bone health
46 antitumor action
47 primary breast
48 testicular
49 nasopharyngeal
50 cell specific
51 protein overexpression
52 oxidative
53 cell chronic
54 acute lymphoblastic
55 term exposure
56 multiple melanoma
57 radical
58 complex a
59 mechanistic
60 beam
61 specific cytotoxic
62 strategy induce tumor
63 ovarian
64 dosimetry
65 intraepithelial
66 lymphocytic
67 arrest
68 effect coffee
69 prostatic
70 online
71 fusion
72 mechanism antitumor
73 population based
74 neutron
75 axillary
76 medium term
77 proliferation
78 interleukin-6 level
79 primary liver
80 allogeneic stem cell
81 activator
82 scattering
83 allogeneic
84 heavy
85 endocrine treatment
86 rectal
87 worker
88 nuclear
89 orthotopic

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

 

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 
instant cancers small cell lung DNA damage
1: Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells. 2006
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 1: Identification of microRNA profiles in docetaxel-resistant human non-small cell lung carcinoma cells (SPC-A1). 2010
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2: The close correlation between 8-hydroxy-2'-deoxyguanosine and epidermal growth factor receptor activating mutation in non-small cell lung cancer. 2010
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3: Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients. 2010
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4: Targeting Epidermal Growth Factor Receptor-Associated Signaling Pathways in Non-Small Cell Lung Cancer Cells: Implication in Radiation Response. 2010
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5: Curcumin Induces Apoptosis in Human Non-small Cell Lung Cancer NCI-H460 Cells through ER Stress and Caspase Cascade- and Mitochondria-dependent Pathways. 2010
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6: Hypermethylation of growth Arrest DNA-damage-inducible gene 45 in non-small cell lung cancer and its relationship with clinicopathologic features. 2010
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7: [ERCC1 expression as a predictor of survival after operation in stage I non-small cell lung cancer patients] 2010
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8: Combinations of DNA Methyltransferase and Histone Deacetylase Inhibitors Induce DNA Damage in Small Cell Lung Cancer Cells: Correlation of Resistance with IFN-Stimulated Gene Expression. 2010
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9: NPRL2 Sensitizes Human Non-Small Cell Lung Cancer (NSCLC) Cells to Cisplatin Treatment by Regulating Key Components in the DNA Repair Pathway. 2010
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10: A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase (MnSOD) Plasmid Liposome (PL) Protection in Patients with Locally Advanced Stage III Non-Small Cell Lung Cancer. 2010
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11: The Nitric Oxide Prodrug JS-K is Effective Against Non-small Cell Lung Cancer Cells in vitro and in vivo : Involvement of Reactive Oxygen Species. 2010
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12: No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non-small cell lung cancer: A meta-analysis. 2010
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13: Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells. 2009
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14: Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. 2009
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15: XPG mRNA expression levels modulate prognosis in resected non-small-cell lung cancer in conjunction with BRCA1 and ERCC1 expression. 2009
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16: Epigenetic inactivation of checkpoint kinase 2 gene in non-small cell lung cancer and its relationship with clinicopathological features. 2009
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17: Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy. 2009
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18: Expression of an X-family DNA polymerase, pol lambda, in the respiratory epithelium of non-small cell lung cancer patients with habitual smoking. 2009
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