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脂联素与胰岛素敏感性的研究动态与基因知识发现

已有 4079 次阅读 2011-1-1 12:11 |个人分类:知识发现|系统分类:论文交流| 基因, 知识发现, 脂联素, 胰岛素敏感

科学家揭示“饥饿激素”作用机制

新发现或将推动开发出新策略用于治疗糖尿病等多种疾病

http://news.sciencenet.cn/htmlnews/2011/1/242265.shtm

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.2277.html

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 

Start A-Literature C-Literature B-list Filter Literature
  A-query: adiponectin
C-query: insulin sensitivity
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1729 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 17162 and can be accessed from the start page after you leave this session. There are 857 terms on the current B-list (373 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

job id # 17162 started Fri Dec 31 23:14:42 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
17162 Search ARROWSMITH A
17162 Search ARROWSMITH A
A_query_raw: adiponectinFri Dec 31 23:16:45 2010

A query = adiponectin started Fri Dec 31 23:16:46 2010
A query resulted in 7447 titles
17162 Search ARROWSMITH C
C_query_raw: insulin sensitivity Fri Dec 31 23:18:10 2010

C: insulin sensitivity 24516

A: pubmed_query_A 7447

AC: ( adiponectin ) AND ( insulin sensitivity ) 1729

C query = insulin sensitivity started Fri Dec 31 23:18:10 2010
C query resulted in 24516 titles
A AND C query resulted in 1729 titles
16321 B-terms ready on Fri Dec 31 23:21:24 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
857 B-terms left after filter executed Fri Dec 31 23:41:55 2010

B-list on Fri Dec 31 23:54:00 2010
1 glut4
2 toll receptor
3 promoter polymorphism
4 jnk
5 akt
6 leptin receptor
7 angiopoietin
8 single nucleotide polymorphism
9 mtor
10 uncoupling protein
11 c jun n
12 leptin receptor gene
13 erk1
14 ccaat enhancer binding
15 polymorphism exon
16 ppargamma
17 srebp-1c
18 ppar gamma
19 visfatin
20 cannabinoid receptor
21 phosphatidylinositol 3-kinase
22 ghrelin
23 c ebp
24 gene polycystic ovary
25 peptide yy
26 gip
27 resistin gene
28 leptin
29 apelin
30 cb1
31 stat3
32 c ebp alpha
33 kora
34 c jun
35 ins-1
36 fat mass
37 ppar alpha
38 irs-1
39 mc4r
40 leptin gene
41 cd40 ligand
42 ampk
43 statin
44 p38 mapk
45 rbp4
46 pparalpha
47 impaired glucose tolerance
48 lkb1
49 hdl
50 angiotensin receptor
51 myostatin
52 diabetes susceptibility gene
53 socs-3
54 insr
55 sirt1
56 dsba
57 glycogen synthase
58 suppressor cytokine signaling
59 phospholipid transfer protein
60 adipogenic gene
61 estrogen receptor alpha
62 pgc-1alpha
63 signal regulated kinase
64 apoe
65 ppar
66 hyperinsulinemia
67 ucp2
68 metabolic syndrome
69 proinsulin
70 genome wide
71 socs3
72 vldl
73 body mass index
74 pten
75 at1
76 beta catenin
77 snp
78 glucose transporter
79 fto gene
80 gene promoter associated
81 irs-2
82 jnk1
83 nf kappab
84 promoter variant
85 rho kinase
86 3-adrenergic receptor gene
87 tcf7l2 gene
88 gene insulin resistance
89 dgat1
90 igfbp-1
91 insulin gene
92 ppardelta
93 candidate gene
94 lipogenic gene
95 il-6
96 fasting glucose
97 irs-1 gene
98 polymorphism promoter
99 insulin receptor substrate
100 pparg
101 bone mineral density
102 pai-1
103 apolipoprotein b
104 il-18
105 glp-1
106 melanocortin receptor
107 foxo1
108 gene associated diabetes
109 polycystic ovary syndrome
110 lamin a c
111 glucagon receptor
112 pi3k
113 mcp-1
114 hhex
115 diabetic nephropathy
116 foxc2
117 ghrelin gene
118 gene diabetic
119 anti mullerian hormone
120 paraoxonase
121 insulin receptor
122 adiposity
123 p38
124 igf i
125 cd40
126 glycogen synthase kinase
127 cd36
128 rankl
129 retinol binding protein
130 cystatin c
131 faah
132 rxr
133 toll
134 tnfalpha
135 fas ligand
136 sp1
137 e deficient mice
138 ikkbeta
139 igf
140 pyy
141 ppard
142 lipase gene
143 lipid metabolism gene
144 hepatic gene
145 resistin
146 gene diabetes
147 c jun nh2-terminal
148 alpha gene
149 cpap
150 inos
151 gene promoter
152 adrenomedullin
153 tlr4
154 hyperlipidemia
155 jnk2
156 insulin level
157 kk
158 il-8
159 autophagy
160 creb
161 gene associated insulin
162 wnt
163 gad
164 jak stat
165 ucp3
166 stearoyl coa desaturase
167 receptor gene expression
168 agrp
169 tnf alpha
170 ob
171 exon
172 candidate gene diabetes
173 jun
174 aryl hydrocarbon receptor
175 ldl
176 alanine aminotransferase
177 ucp1
178 igf-1
179 adenovirus mediated gene
180 mc3r
181 lean body mass
182 peroxisome
183 transcription factor
184 expression gene
185 quantitative trait locus
186 uncoupling protein gene
187 body mass
188 gk
189 apolipoprotein e
190 gene variant
191 polymorphism gene
192 homa
193 kcnj11
194 aminotransferase
195 glut-2
196 gene insulin
197 crp
198 7-like tcf7l2 gene
199 tcf7l2 gene associated
200 triglyceride level
201 lmna
202 ppara
203 regucalcin
204 apolipoprotein a i
205 receptor gene
206 stz
207 abca1
208 c ebpalpha
209 activin
210 map kinase
211 cdna
212 lipoprotein lipase
213 db
214 smrt
215 gene obesity
216 il-10
217 phosphatase tensin homolog
218 enpp1
219 aicar
220 lean
221 vegf
222 mthfr
223 glut1
224 gene associated
225 ap2
226 mafa
227 ppar delta
228 phosphodiesterase 3b
229 iras
230 srebp-1
231 bnp
232 hypercholesterolemia
233 tnf
234 endothelin
235 allele angiotensin
236 gene not
237 gene associated coronary
238 cytokine production
239 cd14
240 torc
241 tyrosine kinase
242 ikk
243 cnr1
244 pco
245 cytokine
246 ace
247 apolipoprotein a
248 promoter associated
249 igf1
250 l6
251 lepr
252 il6
253 glucagon
254 han
255 microrna
256 lipoprotein lipase gene
257 platelet activation
258 cyclin dependent kinase
259 e selectin
260 pon1
261 erk2
262 angiotensin receptor gene
263 diabesity
264 fto gene variant
265 aromatase
266 islet
267 chemokine
268 insulin growth factor
269 transfer protein gene
270 susceptibility gene
271 enos
272 pufa
273 tlr2
274 somatostatin
275 renin
276 psa
277 gh
278 progesterone receptor
279 nucleotide polymorphism snp
280 tumor necrosis factor
281 isoform
282 promoter polymorphism association
283 bcl-2
284 hepatocyte growth factor
285 promoter region
286 enhancer
287 protein kinase
288 diabetes mellitus
289 enzyme gene
290 cyclic nucleotide phosphodiesterase
291 fa
292 grb10
293 fed a
294 mmtv
295 diabetes gene
296 gsk3beta
297 receptor promoter
298 gene encoding
299 apoa i
300 receptor gene insulin
301 grape
302 fasn
303 iga nephropathy
304 g polymorphism
305 transporter
306 hydroxysteroid dehydrogenase
307 promoter activity
308 insulin signaling gene
309 amp response element
310 triglyceride
311 cla
312 promoter
313 pkc
314 acetyl coa carboxylase
315 cd95
316 fibroblast growth factor
317 response element
318 erk
319 oxide synthase gene
320 ubiquitin
321 perilipin
322 angiotensinogen
323 estrogen receptor
324 ucp3 gene
325 neuropeptide y
326 gnrh
327 estrogen receptor beta
328 obese
329 lipase
330 protein gene
331 lipocalin
332 fto gene associated
333 inflammatory bowel disease
334 atherosclerosis
335 prostate cancer
336 association fto gene
337 resistance renin angiotensin
338 gene haplotype
339 intron
340 agouti
341 diabetes
342 chaperone
343 nash
344 differentially expressed gene
345 serum amyloid a
346 bb
347 nefa
348 interleukin
349 str
350 irs2
351 3'-untranslated region
352 pyruvate dehydrogenase kinase
353 anorexia
354 pacap
355 il-6 gene
356 calcium channel
357 hsd1
358 nf
359 nf kappa b
360 atf3
361 angiotensinogen gene
362 cholesterol absorption
363 obesity
364 p70
365 gene family
366 annexin
367 gene response
368 gene patient
369 gene prostate cancer
370 proteinuria
371 factor i
372 polymorphism candidate gene
373 dlk1

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

 

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 
adiponectin glut4 insulin sensitivity
1: Glut4 is Upregulated Despite Decreased Insulin Signaling during Prolonged Fasting in Northern Elephant Seal Pups. 2010
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2: Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes. 2008
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3: Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. 2005
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4: Effect of exercise on the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats. 2005
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5: An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes. 2004
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6: Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. 1999
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 1: Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in non-diabetic chronic heart failure patients independently of body composition. 2010
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2: The effect of mosapride (5HT-4 receptor agonist) on insulin sensitivity and GLUT4 translocation. 2010
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3: High basal cell surface levels of fish GLUT4 are related to reduced sensitivity of insulin-induced translocation toward GGA and AS160 inhibition in adipocytes. 2010
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4: Soybean and sunflower oil-induced insulin resistance correlates with impaired GLUT4 protein expression and translocation specifically in white adipose tissue. 2010
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5: Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium. 2010
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6: Trans-10, cis-12 conjugated linoleic acid inhibits skeletal muscle differentiation and GLUT4 expression independently from NF-kappaB activation. 2010
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7: Intense Acupuncture Normalizes Insulin Sensitivity, Increases Muscle GLUT4 Content, and Improves Lipid Profile in a Rat Model of Polycystic Ovary Syndrome. 2010
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8: The beneficial effects of exercise in rodents are preserved after detraining: a phenomenon unrelated to GLUT4 expression. 2010
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9: Biphasic effects of chronic ethanol exposure on insulin-stimulated glucose uptake in primary cultured rat skeletal muscle cells: role of the Akt pathway and GLUT4. 2010
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10: Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice. 2009
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11: Effect of training with different mechanical loadings on MyHC and GLUT4 changes. 2009
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12: Caveolin, GLUT4 and insulin receptor protein content in human arm and leg muscles. 2009
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13: Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle. 2009
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14: Astragalus polysaccharide improves insulin sensitivity in KKAy mice: Regulation of PKB/GLUT4 signaling in skeletal muscle. 2009
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15: A robust assay measuring GLUT4 translocation in rat myoblasts overexpressing GLUT4-myc and AS160_v2. 2009
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16: Rosiglitazone increases cell surface GLUT4 levels in 3T3-L1 adipocytes through an enhancement of endosomal recycling. 2009
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17: IGF-I increases the recruitment of GLUT4 and GLUT3 glucose transporters on cell surface in hyperthyroidism. 2008
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18: Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling. 2008
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19: Maternal protein restriction during early lactation induces GLUT4 translocation and mTOR/Akt activation in adipocytes of adult rats. 2008
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20: Insulin resistance of pregnancy involves estrogen-induced repression of muscle GLUT4. 2008
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21: Characterization of GLUT4 and calpain expression in healthy human skeletal muscle during fasting and refeeding. 2007
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22: Transcriptional regulation of the GLUT4 gene: from PPAR-gamma and FOXO1 to FFA and inflammation. 2007
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23: Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart. 2007
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24: Expression of GLUT4 mRNA of peripheral tissues and insulin resistance in rats with severe traumatic brain injury. 2007
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25: Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes. 2007
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26: The SUMO conjugating enzyme Ubc9 is a regulator of GLUT4 turnover and targeting to the insulin-responsive storage compartment in 3T3-L1 adipocytes. 2007
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27: Insulin-induced GLUT4 translocation to the plasma membrane is blunted in large compared with small primary fat cells isolated from the same individual. 2007
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28: Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism. 2006
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29: Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. 2006
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30: GLUT4 repression in response to oxidative stress is associated with reciprocal alterations in C/EBP alpha and delta isoforms in 3T3-L1 adipocytes. 2006
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31: Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. 2006
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32: Insulin and contraction stimulate exocytosis, but increased AMP-activated protein kinase activity resulting from oxidative metabolism stress slows endocytosis of GLUT4 in cardiomyocytes. 2005
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33: Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. 2005
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34: [Regulation of insulin sensitivity by subcellular GLUT4 targeting] 2005
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35: [Contents of the glucose transporters GLUT1 and GLUT4 in oxidative and glycolytic muscles of goat kids and adult goats] 2005
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36: Changes in dietary sodium consumption modulate GLUT4 gene expression and early steps of insulin signaling. 2004
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37: GLUT4 but not GLUT1 expression decreases early in the development of feline obesity. 2004
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38: Insulin resistance in adult cardiomyocytes undergoing dedifferentiation: role of GLUT4 expression and translocation. 2004
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39: Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects. 2004
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40: Dietary cod protein restores insulin-induced activation of phosphatidylinositol 3-kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed obese rats. 2003
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41: Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis. 2003
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42: Peroxisome proliferator-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect. 2003
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43: Calorie restriction reduces pinealectomy-induced insulin resistance by improving GLUT4 gene expression and its translocation to the plasma membrane. 2003
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44: Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations. 2002
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45: GLUT4 protein is differently modulated during development of obesity in monosodium glutamate-treated mice. 2002
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46: Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-alpha reduction and GLUT4 expression enhancement. 2002
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47: Thyroid hormone augments GLUT4 expression and insulin-sensitive glucose transport system in differentiating rat brown adipocytes in culture. 2002
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48: Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle. 2001
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49: Arachidonic acid stimulates glucose uptake in 3T3-L1 adipocytes by increasing GLUT1 and GLUT4 levels at the plasma membrane. Evidence for involvement of lipoxygenase metabolites and peroxisome proliferator-activated receptor gamma. 2001
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50: The insulin-sensitive GLUT4 storage compartment is a postendocytic and heterogeneous population recruited by acute exercise. 2001
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51: GLUT4 protein expression in obese and lean 12-month-old rats: insights from different types of data analysis. 2001
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52: Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport. 2001
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53: Impairment of insulin-stimulated GLUT4 translocation in skeletal muscle and adipose tissue in the Tsumura Suzuki obese diabetic mouse: a new genetic animal model of type 2 diabetes. 2001
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54: Stimulation of glucose transport by thyroid hormone in 3T3-L1 adipocytes: increased abundance of GLUT1 and GLUT4 glucose transporter proteins. 2000
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55: Effect of long-term caloric restriction on GLUT4, phosphatidylinositol-3 kinase p85 subunit, and insulin receptor substrate-1 protein levels in rhesus monkey skeletal muscle. 2000
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56: Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytes. 2000
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57: Overexpression of protein tyrosine phosphatase-alpha (PTP-alpha) but not PTP-kappa inhibits translocation of GLUT4 in rat adipose cells. 1999
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58: Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione. 1999
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59: Regulation of GLUT4 protein and glycogen synthase during muscle glycogen synthesis after exercise. 1998
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60: Metabolic and therapeutic lessons from genetic manipulation of GLUT4. 1998
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61: Training in swimming reduces blood pressure and increases muscle glucose transport activity as well as GLUT4 contents in stroke-prone spontaneously hypertensive rats. 1998
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62: Forebrain endothelium expresses GLUT4, the insulin-responsive glucose transporter. 1997
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63: Glucose transport and glucose transporter GLUT4 are regulated by product(s) of intermediary metabolism in cardiomyocytes. 1997
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64: Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter. 1997
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65: Regional variation in adipose tissue insulin action and GLUT4 glucose transporter expression in severely obese premenopausal women. 1997
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66: Characterization of two distinct intracellular GLUT4 membrane populations in muscle fiber. Differential protein composition and sensitivity to insulin. 1997
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67: Metabolic and molecular consequences of modifying GLUT4 expression in skeletal muscle. 1997
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68: Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle. 1996
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69: Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: implications for nutrient partitioning. 1996
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70: Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin. 1995
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71: Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling. 1995
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72: Effect of in vivo thyroid hormone status on insulin signalling and GLUT1 and GLUT4 glucose transport systems in rat adipocytes. 1995
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73: Skeletal muscle GLUT4 protein concentration and aging in humans. 1995
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74: Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells. 1994
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75: Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle. 1993
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76: Expression of GLUT1 and GLUT4 glucose transporters in skeletal muscle of humans with insulin-dependent diabetes mellitus: regulatory effects of metabolic factors. 1992
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77: Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type. 1991
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