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转录因子Sp1通过调控GSDME表达影响细胞焦亡水平
https://www.ebiotrade.com/newsf/2024-1/20240121063200605.htm
未检索到相同的研究文献
新发现
该研究揭示了转录因子Sp1通过促进GSDME的转录表达,提高了细胞在刺激条件下的焦亡水平及对化疗药物的敏感性。为探究细胞程序性死亡调控机制提供了更深入的信息,为肿瘤药物开发提供了新的靶点。
http://www.pubmedplus.cn/P/SearchQuickResult?wd=5271db1b-ee88-43fe-90fb-440395c4c059
https://pubmed.ncbi.nlm.nih.gov/38238307/
Cell Death Dis
. 2024 Jan 18;15(1):66.
doi: 10.1038/s41419-024-06455-6.
Transcription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis
Affiliations expand
PMID: 38238307
PMCID: PMC10796635
1. Transcription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis.
Jiasong Pan,Yuanyuan Li,Wenqing Gao,Qizhou Jiang,Lu Geng,Jin Ding,Suhua Li,Jixi Li
Department of Neurology, Huashan Hospital, State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University, Shanghai, China.
Cell Death Dis (P 2041-4889 E ) 2024 年 15 卷 1 期 66 页
PMID:38238307 相似文献
http://www.pubmedplus.cn/P/SearchQuickResult?wd=742fd26a-0c06-471c-8174-2e7d415a0b66
01. | Pyroptosis | 66 篇 | 65.347% |
02. | Humans | 49 篇 | 48.515% |
03. | Caspase 3 | 46 篇 | 45.545% |
04. | Animals | 40 篇 | 39.604% |
05. | Mice | 32 篇 | 31.683% |
06. | Receptors, Estrogen | 25 篇 | 24.752% |
07. | Cell Line, Tumor | 22 篇 | 21.782% |
08. | Apoptosis | 15 篇 | 14.851% |
09. | Gasdermins | 14 篇 | 13.861% |
10. | Cisplatin | 10 篇 | 9.901% |
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https://fx.wanfangdata.com.cn/keytrends/detail?theme_name=%E8%BD%AC%E5%BD%95%E5%9B%A0%E5%AD%90Sp1%20
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