Bruce Butler. And Zhu A Hoffman, who won a quarter of the 2011 Nobel Prize in Physiology or Medicine. Bruce A. Beutler and Jules A. Hoffmann are professors and chairmen of the Department of Genetics because of their discovery in activating innate immunity and Ralph M. Steinman Beutler is a professor and chairman of the Department of Genetics, Ernest Beutler of Scripps Research Institute in La Jolla, California, his father, a hematologist and medical geneticist, is also a professor and dean of Scripps.

布鲁斯·巴特勒。与朱A.霍夫曼，他获得2011年诺贝尔生理学或医学奖四分之一。布鲁斯·巴特勒（Bruce A. Beutler）和朱尔斯·霍夫曼（Jules A. Hoffmann）因为在激活先天免疫方面的发现以及拉尔夫·斯坦曼（Ralph M.Steinman）Beutler是遗传学系教授及主席，美国加利福尼亚州拉霍亚的斯克里普斯研究所，欧内斯特Beutler，他的父亲，一个血液学家和医学遗传学家，也是Scripps教授和系主任。

https://baike.baidu.com/item/%E5%B8%83%E9%B2%81%E6%96%AF%C2%B7%E5%B7%B4%E7%89%B9%E5%8B%92/6285202?fromModule=lemma_inlink

https://pubmed.ncbi.nlm.nih.gov/23589617/

summary-BeutlerBA-set.txt

http://www.pubmedplus.cn/P/SearchQuickResult?wd=d1c31aa9-e550-409d-8efc-79b7eebc4b00

Abstract

Nucleic acid (NA)-sensing TLRs (NA-TLRs) promote the induction of anti-nuclear Abs in systemic lupus erythematosus. However, the extent to which other nonnuclear pathogenic autoantibody specificities that occur in lupus and independently in other autoimmune diseases depend on NA-TLRs, and which immune cells require NA-TLRs in systemic autoimmunity, remains to be determined. Using Unc93b1(3d) lupus-prone mice that lack NA-TLR signaling, we found that all pathogenic nonnuclear autoantibody specificities examined, even anti-RBC, required NA-TLRs. Furthermore, we document that NA-TLRs in B cells were required for the development of antichromatin and rheumatoid factor. These findings support a unifying NA-TLR-mediated mechanism of autoantibody production that has both pathophysiological and therapeutic implications for systemic lupus erythematosus and several other humoral-mediated autoimmune diseases. In particular, our findings suggest that targeting of NA-TLR signaling in B cells alone would be sufficient to specifically block production of a broad diversity of autoantibodies.

Conflict of interest statement

Disclosures

The authors have no financial conflicts of interest.

Figures

FIGURE 1 

NA-TLRs are required for development…

FIGURE 2 

Lupus-associated dermatitis in MRL- Fas…

FIGURE 3 

Total isotype and subclass Ig…

FIGURE 4 

ANA specificities and IgM RF…

FIGURE 5 

Nonnuclear autoantibody levels in 3d…

FIGURE 6 

The effect of NA-TLR deficiency…

All figures (7)

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Publication types

• Research Support, N.I.H., Extramural

• Research Support, Non-U.S. Gov't

MeSH terms

• Animals

• Antibodies, Antinuclear / immunology*

• Antibody-Producing Cells / immunology

• Autoantibodies / immunology

• B-Lymphocytes / immunology*

• Bone Marrow Cells / cytology

• CD4-Positive T-Lymphocytes / immunology

• CD8-Positive T-Lymphocytes / immunology

• Chromatin / immunology

• Dendritic Cells

• Female

• Immunologic Deficiency Syndromes

• Lupus Erythematosus, Systemic / immunology

• Lymphocyte Activation / immunology

• Macrophages / immunology

• Membrane Glycoproteins / immunology*

• Membrane Transport Proteins / immunology

• Mice

• Mice, Inbred NZB

• Myeloid Differentiation Factor 88 / immunology

• Nucleic Acids / immunology*

• Primary Immunodeficiency Diseases

• Rheumatoid Factor / immunology

• Ribonucleoproteins / immunology

• Signal Transduction

• Toll-Like Receptor 7 / immunology*

• Toll-Like Receptor 9 / immunology*

Substances

• Antibodies, Antinuclear

• Autoantibodies

• Chromatin

• Membrane Glycoproteins

• Membrane Transport Proteins

• Myd88 protein, mouse

• Myeloid Differentiation Factor 88

• Nucleic Acids

• Ribonucleoproteins

• Tlr7 protein, mouse

• Tlr9 protein, mouse

• Toll-Like Receptor 7

• Toll-Like Receptor 9

• UNC93B1 protein, mouse

• Rheumatoid Factor

Supplementary concepts

• MYD88 Deficiency

Related information

• GEO Profiles

• Gene

• HomoloGene

• Nucleotide (RefSeq)

• Nucleotide (RefSeq)

• Nucleotide (Weighted)

• Protein (RefSeq)

• Protein (Weighted)

• Taxonomy via GenBank

• UniGene

Grant support

• R01 AR053731/AR/NIAMS NIH HHS/United States

• R01 AR039555/AR/NIAMS NIH HHS/United States

• ES14847/ES/NIEHS NIH HHS/United States

• AR53731/AR/NIAMS NIH HHS/United States

• AR39555/AR/NIAMS NIH HHS/United States

Show all 8 grants

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