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缪慧慧博士在《分子神经生物学》(Mol Neurobiol)发表论文

已有 4531 次阅读 2017-10-9 09:12 |个人分类:神经科学|系统分类:论文交流


异氟醚、地氟醚加手术对阿尔茨海默病转基因小鼠认知功能的不同影响。

1.

Miao H . Dong Y . Zhang Y . Zheng H . Shen Y . Crosby G . Culley DJ . Marcantonio ER . Xie Z .
来源: Mol Neurobiol ( P 0893-7648 E 1559-1182 ) IF:6.19(2016) H指数:60 年: 2017
PMID: 28986748 [Pubmed] 神经科学,2区



2017 Oct 6. doi: 10.1007/s12035-017-0787-9. [Epub ahead of print]

Anesthetic Isoflurane or Desflurane Plus Surgery Differently Affects Cognitive Function in Alzheimer's Disease Transgenic Mice.

Author information

1
Department of Anesthesia, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.
2
Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4310, Charlestown, MA, 02129-2060, USA.
3
Massachusetts General Hospital Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
4
Department of Psychiatry, Tenth People's Hospital of Tongji University, Shanghai, 200072, People's Republic of China.
5
Department of Anesthesia, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
6
Divisions of General Medicine and Primary Care and Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
7
Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4310, Charlestown, MA, 02129-2060, USA. zxie@mgh.harvard.edu.

Abstract

Anesthesia/surgery could be associated with cognitive impairment and Alzheimer's disease neuropathogenesis. However, whether surgery under different anesthetics has different effects on cognitive function remains largely unknown. We therefore set out to compare effects of anesthetic isoflurane or desflurane plus surgery on cognitive function and hippocampus levels of synaptic marker (postsynaptic density-95 and synaptophysin) and ATP. Five-month-old AD Transgenic (Tg) (FAD5X) and wild-type male mice received isoflurane or desflurane plus abdominal surgery. We assessed cognitive function in Barnes maze and measured hippocampus levels of postsynaptic density-95, synaptophysin, and ATP in the mice. We determined whether vitamin K2 could mitigate these anesthesia/surgery-induced changes. Isoflurane, but not desflurane, plus surgery increased escape latency and escape distance in Barnes maze probe test and reduced postsynaptic density-95, synaptophysin, and ATP levels as compared to control condition in AD Tg mice. Vitamin K2 attenuated the anesthesia/surgery-induced changes in the AD Tg mice. These findings suggest that isoflurane, but not desflurane, plus surgery might induce cognitive impairment via causing brain energy deficits. Pending confirmative studies in both animals and humans suggest desflurane could be a better choice for AD patients when surgery is needed. Moreover, vitamin K2 could treat cognitive deficiency associated with anesthesia and surgery.

KEYWORDS:

ATP; Alzheimer’s disease; Anesthesia/surgery; Cognitive deficiency; Desflurane; Isoflurane; Synapse; Transgenic mice

PMID:
28986748
DOI:
10.1007/s12035-017-0787-9

https://www.ncbi.nlm.nih.gov/pubmed/28986748

缪博士获得2017年度国自基金资助

http://blog.sciencenet.cn/blog-280034-1071547.html

缪博士哈佛大学麻省总医院(MGH)博士后

http://blog.sciencenet.cn/blog-280034-1027399.html

祝贺缪博士  获得国自基金20万  

缪博士哈佛大学麻省总医院(MGH)博士后

http://blog.sciencenet.cn/blog-280034-1027399.html

欢迎缪博士美国归来  http://blog.sciencenet.cn/blog-280034-999396.html

热度 1 2016-8-29 08:11缪博士在美国哈佛医学院研究工作期满,近日回国。热烈欢迎! 寄语缪博士 http://blog.sciencenet.cn/blog-280034-915030.html 缪博士,你好! 9月10日,你就要去美国波士顿哈佛大学,麻省总医院做科学研究,我们十分高兴,祝贺你,支持你。 哈佛大学是世界最好的大学,麻省总医院是世界最好的医院,大家很羡 ...1002 次阅读|1 个评论











1.

Miao H . Dong Y . Zhang Y . Zheng H . Shen Y . Crosby G . Culley DJ . Marcantonio ER . Xie Z .
来源: Mol Neurobiol ( P 0893-7648 E 1559-1182 ) IF:6.19(2016) H指数:60 年: 2017








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