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有关诺贝尔奖获奖关键论文(Key publications)发表在了哪些杂志?大家众说纷纭。本博文对此进行了总结。由于数量庞大,本博文仅仅总结2006-2016年生理医学的论文。希望起到抛砖引玉作用,以便同行总结其他诺贝尔奖相关论文发表的杂志。
总数64篇之中,nature 22篇,占34%。science 12篇,占19%,cell 9篇,占14%。CNS一共占67%。简单的统计结果是:2006-2016年生理医学诺贝尔奖的论文多数发表在最顶端杂志。
在这些论文中,多数是新发现,包括机理发现,治疗方法的发现。
如何创新?如何做到重大创新?仔细阅读这些论文,给我们的科研树立一个思路,树立一个典范。以前,生物医学方面的纯理论有一些,例如达尔文的进化论,拉马克的用进废退学说。但目前生物医学方面的纯理论是很少的,多数是实验性质的。少数是在实验基础之上,上升为理论的。2006-2016年的生物医学诺贝尔奖多数都是在实验基础上提出了理论学说的,把实验上升为理论的,也即把现象上升为规律。这一点恰恰是他们的高明之处,也是值得我们学习之处。
2006年
Andrew Fireand/Craig C. Mello
A, Fire,S.Q. Xu, M.K. Montgomery, S.A. Kostas, S. E. Driver,C.C. Mello: Potent and specific genetic interference by double-stranded RNAinCaenorhabditis elegans. In: Nature.391/1998, S.806-811
2007年
Mario Capecchi
1. Thomas, K. R.; Capecchi, M. R. (1987)."Site-directedmutagenesis by gene targeting in mouse embryo-derived stemcells". Cell. 51 (3):503–512.
2. Mansour, S. L.; Thomas, K. R.; Capecchi, M. R.(1988)."Disruption of the proto-oncogene int-2 in mouse embryo-derivedstemcells: A general strategy for targeting mutations tonon-selectablegenes". Nature. 336 (6197): 348–352.
3. Capecchi, M. R. (1980). "High efficiencytransformation bydirect microinjection of DNA into cultured mammaliancells". Cell. 22 (2 Pt 2):479–488. .
4.Chisaka, O.; Capecchi, M. R. (1991). "Regionallyrestricteddevelopmental defects resulting from targeted disruption of the mousehomeoboxgene hox-1.5".Nature. 350 (6318): 473–479.
5.Thomas,K. R.; Folger, K. R.; Capecchi, M. R. (1986)."High frequency targeting ofgenes to specific sites in the mammaliangenome". Cell. 44 (3):419–428.
Martin Evans
1. Evans M,Kaufman M (July 1981)."Establishment in culture of pluripotential cellsfrom mouse embryos". Nature.292 (5819):154–6. .
2. Martin G (December 1981). "Isolation of a pluripotent cellline from earlymouse embryos cultured in medium conditioned by teratocarcinomastemcells".Proc Natl Acad Sci USA. 78 (12):7634–8. .
3. Bradley A, Evans M, KaufmanMH,Robertson E (1984). "Formation of germ-line chimaeras fromembryo-derivedteratocarcinoma cell lines". Nature. 309 (5965):255–256.
4. Robertson E; Bradley, A.;Kuehn, M.;Evans, M. (1986). "Germ-line transmission of genes introducedinto culturedpluripotential cells by retroviral vector".Nature. 323 (6087):445–448. .
5. Kuehn MR, Bradley A, RobertsonEJ,Evans MJ (1987). "A potential animal model for Lesch-Nyhan syndromethroughintroduction of HPRT mutations into mice".Nature. 326 (5819):295–298. .
Oliver Smithies
1.DoetschmanT, Gregg R G, Maeda N, et al. Targettedcorrection of a mutant HPRT gene inmouse embryonic stem cells[J]. Nature,1987, 330(6148): 576-578.
2.SnouwaertJ N, Brigman K K, Latour A M, et al. An AnimalModel for Cystic Fibrosis Made byGene Targeting[J]. Science, 1992, 257(5073):1083-1088.
3.KregeJ H, Hodgin J B, Couse J F, et al. Generation andreproductive phenotypes ofmice lacking estrogen receptor β[J]. Proceedings ofthe National Academy ofSciences of the United States of America, 1998, 95(26):15677-15682.
2008年
Harald zur Hausen
1. Henle,Werner (1967-09-01). "Herpes-Type Virus and Chromosome Marker in NormalLeukocytesafter Growth with Irradiated Burkitt Cells | Science" (PDF). Science. 157:1064–1065.
2. M Dürst;L Gissmann; H Ikenberg; H zur Hausen (1983-06-01). "Apapillomavirus DNA from a cervical carcinoma andits prevalence in cancer biopsysamples from different geographic regions". PNAS. 80:3812.
3. Boshart,M; Gissmann, L;Ikenberg, H; Kleinheinz, A; Scheurlen, W; Hausen, H (1984). "A new type ofpapillomavirus DNA, its presence ingenital cancer biopsies and in cell linesderived from cervical cancer" (PDF).EMBOJ. 3:1151–7.
Françoise Barré-Sinoussi
1. Barré-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S,Gruest J,Dauguet C, Axler-Blin C, Vézinet-Brun F, Rouzioux C, Rozenbaum W,Montagnier L(1983). "Isolation of a T-lymphotropic retrovirus from apatient at riskfor acquired immune deficiency syndrome (AIDS)". Science. 220 (4599):868–871.
2.MossA R, Osmond D, Bacchetti P, et al. RISK FACTORS FORAIDS AND HIV SEROPOSITIVITYIN HOMOSEXUAL MEN[J]. American Journal ofEpidemiology, 1987, 125(6): 1035-1047.
3.BarresinoussiF. HIV as the cause of AIDS[J]. The Lancet,1996, 348(9019): 31-35.
Luc Montagnier
BarresinoussiF, Chermann J C, Rey F, et al.Isolation of a T-lymphotropic retrovirus from apatient at risk for acquiredimmune deficiency syndrome (AIDS).[J]. Science,1983, 220(4599): 868-871.
2009年
Elizabeth Blackburn, Carol W. Greider and Jack W.Szostak
1.ShampayJ, Szostak J W, Blackburn E H, et al. DNA sequencesof telomeres maintained inyeast[J]. Nature, 1984, 310(5973): 154-157.
2.Greider, C. W.; Blackburn, E. H. (1985)."Identification of aspecific telomere terminal transferase activity inTetrahymena extracts". Cell.43 (2Pt1): 405–413.
3.BudarfM L, Blackburn E H. Chromatin structure of thetelomeric region and3'-nontranscribed spacer of Tetrahymena ribosomal RNAgenes.[J]. Journal ofBiological Chemistry, 1986, 261(1): 363-369.
4.GreiderC W, Blackburn E H. A telomeric sequence in the RNAof Tetrahymena telomeraserequired for telomere repeat synthesis[J]. Nature,1989, 337(6205): 331-337.
5.DunnB W, Szauter P, Pardue M L, et al. Transfer of yeasttelomeres to linearplasmids by recombination.[J]. Cell, 1984, 39(1): 191-201.
2010年
Robert Edwards
Steptoe,P. C.; Edwards, R. G. (1978)."Birth After the Reimplantation of a HumanEmbryo". The Lancet. 312 (8085):366
2011年
Bruce Beutler
Poltorak, A., et al. Defective LPS signaling inC3H/HeJ andC57BL/10ScCr mice: mutations in Tlr4 gene. Science282(5396):2085-8, 1998
Jules A. Hoffmann
1.Song,W.Y.; et al. (1995). "A receptor kinase-likeprotein encoded by the ricedisease resistance gene, XA21". Science.270(5243): 1804–1806.
2.Lemaitre,B.; Nicolas, E.; Michaut, L.; Reichhart, J. M.;Hoffmann, J. A. (1996)."The dorsoventral regulatory gene cassettespätzle/Toll/cactus controls thepotent antifungal response in Drosophilaadults". Cell. 86 (6):973–983.
Ralph M. Steinman
1.SteinmanRM, Cohn ZA (1973). "Identification of anovel cell type in peripheral lymphoidorgans of mice. I. Morphology,quantitation, tissue distribution". J. Exp. Med. 137 (5):1142–62.
2.SteinmanR M, Nussenzweig M C. Dendritic cells: featuresand functions.[J]. ImmunologicalReviews, 1980, 53(1): 127-147.
2012年
John Gurdon
1.Gurdon,J. B.; Elsdale, T. R.; Fischberg, M. (1958). "SexuallyMature Individualsof Xenopus laevis from the Transplantation of SingleSomaticNuclei".Nature. 182 (4627):64–65.
2.Gurdon,J. B. (1962). "The developmental capacity ofnuclei taken from intestinalepithelium cells of feeding tadpoles". Journal ofembryology andexperimental morphology. 10: 622–640.
3.Gurdon,J. B.; Lane, C. D.; Woodland, H. R.; Marbaix, G.(1971). "Use of Frog Eggsand Oocytes for the Study of Messenger RNA andits Translation in LivingCells". Nature. 233 (5316):177–182.
4.Simonsson,S.; Gurdon, J. (2004). "DNA demethylationis necessary for the epigeneticreprogramming of somatic cell nuclei". Nature Cell Biology. 6 (10):984–990.
Shinya Yamanaka
1. Takahashi, K.;Yamanaka,S. (2006). "Induction of Pluripotent Stem Cells from MouseEmbryonic andAdult Fibroblast Cultures by Defined Factors".Cell. 126 (4):663–76.
2. Takahashi,K.; Tanabe, K.;Ohnuki, M.; Narita, M.; Ichisaka, T.; Tomoda, K.; Yamanaka, S.(2007)."Induction of Pluripotent Stem Cells from Adult Human FibroblastsbyDefined Factors". Cell. 131 (5):861–872.
3. Okita,K.; Ichisaka, T.;Yamanaka, S. (2007). "Generation of germline-competentinduced pluripotentstem cells".Nature. 448 (7151):313–317.
2013年
James Rothman
1. Miesenböck, G.; Rothman, J. E.(1997). "Patterns of synaptic activity inneural networksrecorded by light emission from synaptolucins". Proceedingsof the National Academy ofSciences of the United States of America. 94(7):3402–3407.
2. Miesenböck,G.; De Angelis, D. A.; Rothman, J.E. (1998). "Visualizing secretion andsynaptic transmission withpH-sensitive green fluorescent proteins". Nature. 394 (6689):192–195.
Randy Schekman
1.Deshaies,R.J.; Koch, B. D.; Werner-Washburne, M.; Craig, E. A.; Schekman, R.(1988)."A subfamily of stress proteins facilitates translocation ofsecretory andmitochondrial precursor polypeptides". Nature. 332 (6167):800–805.
2.Novick,P.;Field, C.; Schekman, R. (1980). "Identification of 23complementationgroups required for post-translational events in the yeastsecretorypathway". Cell. 21 (1):205–215.
3.Schekman,R.; Orci, L. (1996). "Coat Proteins andVesicle Budding". Science.271 (5255): 1526–1533.
Thomas C. Südhof
1.SudhofT C, Czernik A J, Kao H T, et al. Synapsins: mosaicsof shared and individualdomains in a family of synaptic vesiclephosphoproteins[J]. Science, 1989,245(4925): 1474-1480.
2.SudhofT C, Jahn R. Proteins of synaptic vesicles involvedin exocytosis and membranerecycling[J]. Neuron, 1991, 6(5): 665-677.
2014年
John O'Keefe
1.O'Keefej, D. J. (1971). "The hippocampus as a spatialmap. Preliminary evidencefrom unit activity in the freely-moving rat".Brain Research. 34 (1):171–175.
2.O'Keefe,J (1976). "Place units in the hippocampus ofthe freely moving rat".Experimental neurology. 51 (1):78–109.
3.O'Keefe,J.; Burgess, N. (1996). "Geometricdeterminants of the place fields ofhippocampal neurons". Nature. 381(6581):425–428.
May-Britt Moser and Edvard Moser
1.Brun, V.H., Otnæss, M.K.,Molden, S., Steffenach, H.-A., Witter, M.P., Moser,M.- ., Moser, E.I. (2002).Place cells and place representation maintained bydirectentorhinal-hippocampal circuitry. Science, 296,2089-2284
2.Sargolini, F., Fyhn, M.,Hafting, T., McNaughton, B.L., Witter, M.P., Moser,M.-B., and Moser, E.I.(2006). Conjunctive representation of position, directionand velocity inentorhinal cortex. Science, 312,754-758.
3.Fyhn, M., Hafting, T., Treves,A., Moser, M.-B. and Moser, E.I. (2007).Hippocampal remapping and gridrealignment in entorhinal cortex. Nature, 446,190-194.
4.Hafting, T., Fyhn, M.,Bonnevie, T., Moser, M.-B. and Moser, E.I. (2008).Hippocampus-independentphase precession in entorhinal grid cells. Nature 453, 1248-1252.
2015年
屠呦呦
1.青蒿素结构研究协作组.一种新型的倍半萜内酯——青蒿素.科学通报,1977,(3):142.
2.刘静明,倪慕云,樊菊芬,屠呦呦等.青蒿素(Arteannuin)的结构和反应.化学学报,1979,37(2):129-142.
3.青蒿研究协作组.抗疟新药青蒿素的研究.药学通报,1979,14 (2):49-53.
Satoshi ōmura
1.Burg,R. W.; Miller, B.M.; Baker, E. E.; Birnbaum, J.; Currie, S. A.; Hartman, R.;Kong, Y.-L.;Monaghan, R.; Olson, G.; Putter, I.; Tunac, J. B.; Wallick, H.;Stapley, E. O.;Oiwa, R.; ōmura, S. (1979). "Avermectins, new family of potent anthelminticagents:producing organism and fermentation". Antimicrob. Agents andChemother. 15: 61–367.
2.Hopwood,D.A.;Malphatida, F.; Kieser, H.M.; Ikeda, J.; Juncan, J.; Fujii, B.A.M.; Rudd,H.;Floss, G.; ōmura, S. (1984)."Productionof 'hybrid' antibiotics by geneticengineering". Nature. 314 (6012):642–644.
3.Ikeda, H.; Nonomiya, T.; Usami, M.; Ohta, T; ōmura, S. (1999). "Organizationof the biosynthetic gene cluster forthe polyketide anthelmintic macrolideavermectin in Streptomycesavermitilis". Proc. Natl. Acad. Sci.96: 9509–9514.
William C. Campbell
Campbell W C, Fisher M H, Stapley E O, et al.Ivermectin: apotent new antiparasitic agent.[J]. Science, 1983, 221(4613):823.
2016年
Yoshinori Ohsumi
1.Takeshige,K.,Baba, M., Tsuboi, S., Noda, T. and Ohsumi, Y. (1992). Autophagy inyeastdemonstrated with proteinase-deficient mutants and conditions foritsinduction. Journal of Cell Biology 119, 301-311
2.Tsukada,M.and Ohsumi, Y. (1993). Isolation and characterization of autophagy-defectivemutantsofSaccharomycescervisiae. FEBS Letters 333, 169-174
3.Mizushima,N.,Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M.D., Klionsky,D.J.,Ohsumi, 3.M. and Ohsumi, Y. (1998). A protein conjugation systemessential forautophagy. Nature 395, 395-398
4.Ichimura,Y.,Kirisako T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N.,Mizushima, N.,Tanida, I., Kominami, E., Ohsumi, M., Noda, T. and Ohsumi, Y.(2000). Aubiquitin-like system mediates protein lipidation. Nature, 408,488-492
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