In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases Abstract How metastases develop is not well understood and no genetic mutations have been reported as specific metastatic drivers. Here we have addressed the idea that epigenetic reprogrammi ...
2015年1月13日，国际学术期刊 Journal of Molecular Cell Biology 在线发表了中国科学院上海生命科学研究院生物化学与细胞生物学研究所陈德桂研究组的最新研究成果 “ JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice ”，揭示了软 ...
Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN Abstract Tumor cells secrete not only a variety of soluble factors, but also extracellular vesicles that are known to support the establishment of a favorable tumor niche by i ...
Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung Abstract The Hippo/Yap pathway is a well-conserved signaling cascade that regulates cell proliferation and differentiation to control organ size and stem/progenit ...
Molecular dynamics reveal a novel kinase−substrate interface that regulates protein translation Abstract A key control point in gene expression is the initiation of protein translation, with a universal stress response being constituted by inhibitory phosphorylation of the eukar ...
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