On the cover: LSD1 phosphorylation plays a critical role in circadian rhythmicity and phase resetting in vivo. In this issue, Nam et al. (pp. 791–805) demonstrate a new mechanism of circadian signal-modulated LSD1 at an organism level. LSD1 is phosphorylated by PKCa either in a circadian r ...
On the cover: The cover tells the story, reported in Xu et al. (pp. 909–921), of an induced pluripotent stem cell (iPSC, shown here in a red t-shirt) that cannot make muscle. When a “bully” researcher tries to steal the postdoctoral fellow working with the iPSC, it's back to the lab, ...
Proc Natl Acad Sci U S A. 2013 Sep 16. A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis. abstract: In multicellular organisms, germ cells carry the hereditary material from one generation to the ne ...
Cell minireview: Long Noncoding RNAs Usher In a New Era in the Biology of Enhancers summary: Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understand ...