1 、研究发现人类胚胎发生和神经发生阶段的突变率高于成年时期。 Science . 2017Dec 7. pii: eaan8690. doi: 10.1126/science.aan8690. Different mutational rates and mechanisms in humancells at pregastrulation and neurogenesis. Abstract Somatic mosaicism in the human brain may alterfuncti ...
2017 年阿尔茨海默病十大研究进展 第一位:增强线粒体蛋白质质控降低 Aβ 神经毒性 Nature. 2017 Dec 14;552(7684):187-193. Enhancingmitochondrial proteostasis reduces amyloid-β proteotoxicity. Abstract Alzheimer's disease is a common and devastating diseasecharacter ...
2017 年帕金森病十大研究进展 第一位:Nature报道α-synuclein可能是引起PD中T细胞免疫异常的关键抗原,提示PD的发生可能与自身免疫机制相关。 Sulzer et al. T cells from patients with Parkinson'sdisease recognizeα-synuclein peptides. Nature. 2017 Jun29;546(7660):656-661. ...