在酵母命运抉择蛋白调控网络的建模和随机模拟方面的工作被Scientific Reports杂志接收发表。

http://www.nature.com/srep/2014/140721/srep05764/full/srep05764.html

The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast

Abstract
To gain insights into the mechanisms of cell fate decision in a noisy environment, the effects of intrinsic and extrinsic noises on cell fate are explored at the single cell level. Specifically, we theoretically define the impulse of Cln1/2 as an indication of cell fates. The strong dependence between the impulse of Cln1/2 and cell fates is exhibited. Based on the simulation results, we
illustrate that increasing intrinsic fluctuations causes the parallel shift of the separation ratio of
Whi5P but that increasing extrinsic fluctuations leads to the mixture of different cell fates. Our
quantitative study also suggests that the strengths of intrinsic and extrinsic noises around an
approximate linear model can ensure a high accuracy of cell fate selection. Furthermore, this
study demonstrates that the selection of cell fates is an entropy-decreasing process. In addition,
we reveal that cell fates are significantly correlated with the range of entropy decreases.