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咖啡与癌症关联的基因知识发现

已有 3287 次阅读 2013-11-5 13:48 |个人分类:知识发现|系统分类:科研笔记| 知识, 咖啡


咖啡防肝癌国际研究进展与文献分析  http://blog.sciencenet.cn/blog-280034-739026.html


意大利研究人员发现,每天饮用三杯咖啡可降低患肝癌风险。论文2013年5月6日在线发表于《临床胃肠病学和肝病学杂志》(Clinical Gastroenterology andHepatology)。

研究人员收集了1996年到2012年9月之间的文章进行荟萃分析,最终纳入了16项高质量研究,共3153例病例。研究中的部分数据表明,每天饮用三杯咖啡可减少患肝癌风险达50%以上。研究人员表示,原发性肝癌是可以避免的,通过接种乙肝病毒疫苗,控制丙型肝炎病毒传播和减少饮酒三个措施,原则上可避免90%以上的原发性肝癌。

(来源:Clinical Gastroenterology and Hepatologyhttp://www.ncbi.nlm.nih.gov/pubmed/?term=23660416



A-LiteratureC-LiteratureB-listFilterLiterature
A-query: Coffee
C-query: cancer

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1329 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 12686 and can be accessed from the start page after you leave this session. There are 901 terms on the current B-list (182 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 

job id # 12686 started Mon Nov 4 23:45:26 2013
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: Coffee Mon Nov 4 23:45:53 2013

A query = Coffee started Mon Nov 4 23:45:53 2013
A query resulted in 9758 titles
C_query_raw: Coffee Mon Nov 4 23:45:56 2013

C: Coffee 9758

A: pubmed_query_A 9758

AC: ( Coffee ) AND ( Coffee ) 9758

C_query_raw: cancer Mon Nov 4 23:46:06 2013

C: cancer 2861986

A: pubmed_query_A 9758

AC: ( Coffee ) AND ( cancer ) 1329

C_query_raw: cancer Mon Nov 4 23:46:09 2013

C: cancer 2861986

A: pubmed_query_A 9758

AC: ( Coffee ) AND ( cancer ) 1329

C query = cancer started Mon Nov 4 23:46:09 2013
C query resulted in 50000 titles
A AND C query resulted in 1329 titles
14069 B-terms ready on Mon Nov 4 23:46:43 2013

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
901 B-terms left after filter executed Mon Nov 4 23:47:18 2013

B-list on Mon Nov 4 23:50:32 2013
1 akt
2 jnk
3 nf kappab
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85 iga nephropathy
86 nrf-1
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StartA-LiteratureC-LiteratureB-listFilterLiterature
AB literature


B-term


BC literature


Coffee aktcancer
1:Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-A(y) Mice. 2012
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2: The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK. 2009
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1: Gambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells. 2013
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2: Huaier Aqueous Extract Inhibits Ovarian Cancer Cell Motility via the AKT/GSK3beta/beta-Catenin Pathway. 2013
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3: PI 3-kinase independent role for AKT in F-actin regulation during outer segment phagocytosis by RPE cells. 2013
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4: Dual inhibition of autophagy and the AKT pathway in prostate cancer. 2013
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5: FAM 83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. 2013
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6: Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity. 2013
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7: Effects of celecoxib treatment over the AKT pathway in head and neck squamous cell carcinoma. 2013
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8: Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W. 2013
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9: Loss of connective tissue growth factor as an unfavorable prognosis factor activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma. 2013
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10: MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways. 2013
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