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ceramide-1-phosphate转运蛋白与癌症和炎症研究的知识发现

已有 4088 次阅读 2013-8-2 14:25 |个人分类:知识发现|系统分类:科研笔记| 知识, 转运

Arrowsmith知识发现系统用于科研选题 http://blog.sciencenet.cn/blog-280034-713113.html

ceramide-1-phosphate转运蛋白与癌症和炎症研究的知识发现

Nature重要发现:将癌症、炎症一网打尽

在癌症研究中,发现一个在癌症中起作用的新蛋白,就如同找到了一个宝库的钥匙和藏宝图:沿着线索追踪,最终就会获得丰厚的回报。发表在《自然》(Nature)杂志上的一项新研究,发现了一个称之为CPTP(ceramide-1-phosphate转运蛋白)的新型蛋白,为我们带来了这一希望。该研究发现可能最终促使开发出治疗各种癌症和炎症、血栓形成等其他疾病的新药物。http://www.ebiotrade.com/newsf/2013-8/201381104007575.htm

A-query: ceramide-1-phosphate transfer protein
C-query: cancer and inflammation

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 6072 and can be accessed from the start page after you leave this session. There are 36 terms on the current B-list (发现13个重要的相关知识概念 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=6072

job id # 6072 started Fri Aug 2 01:20:19 2013
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: ceramide-1-phosphate transfer protein Fri Aug 2 01:20:25 2013

A query = ceramide-1-phosphate transfer protein started Fri Aug 2 01:20:26 2013
A query resulted in 4 titles
C_query_raw: ceramide-1-phosphate transfer protein Fri Aug 2 01:20:28 2013

C: ceramide-1-phosphate transfer protein 4

A: pubmed_query_A 4

AC: ( ceramide-1-phosphate transfer protein ) AND ( ceramide-1-phosphate transfer protein ) 4

C_query_raw: cancer and inflammation Fri Aug 2 01:21:28 2013

C: cancer and inflammation 44299

A: pubmed_query_A 4

AC: ( ceramide-1-phosphate transfer protein ) AND ( cancer and inflammation ) 1

C_query_raw: cancer and inflammation Fri Aug 2 01:21:31 2013

C: cancer and inflammation 44299

A: pubmed_query_A 4

AC: ( ceramide-1-phosphate transfer protein ) AND ( cancer and inflammation ) 1

C query = cancer and inflammation started Fri Aug 2 01:21:32 2013
C query resulted in 44299 titles
A AND C query resulted in 1 titles
36 B-terms ready on Fri Aug 2 01:22:22 2013

B-list on Fri Aug 2 01:25:53 2013
1 sp1
2 ceramide
3 bioactive sphingolipid
4 cathepsin
5 ceramide kinase
6 sp3
7 kinase
8 sphingolipid
9 protein gene
10 bioactive
11 1-phosphate
12 ceramide 1-phosphate
13 cathepsin d

 

知识发现示例:请查阅AC研究论文或BC研究论文,是否对你有所启发和参考意义。

ceramide-1-phosphate transfer ... cathepsin cancer and inflammation

 

Start A-Literature C-Literature B-list Filter Literature
AB literature

 

B-term

 

BC literature

 

ceramide-1-phosphate transfer ... cathepsin cancer and inflammation
1: Complex modulation of peptidolytic activity of cathepsin D by sphingolipids. 2011
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1: Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice. 2012
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2: Macrophage cathepsin K promotes prostate tumor progression in bone. 2012
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3:Cathepsin B Controls the Persistence of Memory CD8+ T Lymphocytes. 2012
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4: Fluorescent nitrile-based inhibitors of cysteine cathepsins. 2012
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5: Development of activity-based probes for cathepsin X. 2011
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6: Depletion of cathepsin D by transglutaminase 2 through protein cross-linking promotes cell survival. 2011
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7: Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis. 2010
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8:Cathepsins and their involvement in immune responses. 2010
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9: Beneficial effects of cathepsin inhibition to prevent chemotherapy-induced intestinal mucositis. 2010
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10: Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation. 2010
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11: [Serum activity of chitotriosidase, lysozyme and cathepsin H in patients with lung cancer and patients with inflammatory exudate (preliminary report)] 2009
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12: Levels of cathepsins S and H in pleural fluids of inflammatory and neoplastic origin. 2009
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13: Cysteine cathepsins are not critical for TNF-alpha-induced cell death in T98G and U937 cells. 2009
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14: Bone marrow-derived cathepsin K cleaves SPARC in bone metastasis. 2009
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15: Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. 2008
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16:Cathepsin B, cathepsin H, cathepsin X and cystatin C in sera of patients with early-stage and inflammatory breast cancer. 2008
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17:Cathepsin K in the bone microenvironment: link between obesity and prostate cancer? 2007
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18: Inhibitors of cathepsin B. 2006
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19: Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. 2005
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20:Cathepsins B, H, and L activities in urine of patients with transitional cell carcinoma of the bladder. 2002
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21:Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells. 2002
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22: Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis. 2001
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23: Expression of cathepsins B and L in human lung epithelial cells is regulated by cytokines. 2000
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24: Review: peptidases and peptidase inhibitors in the pathogenesis of diseases. Disturbances in the ubiquitin-mediated proteolytic system. Protease-antiprotease imbalance in inflammatory reactions. Role of cathepsins in tumour progression. 2000
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25: Comparative localization of cathepsin B protein and activity in colorectal cancer. 2000
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26: Inflammatory mediators regulate cathepsin S in macrophages and microglia: A role in attenuating heparan sulfate interactions. 1999
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27: Squamous cell carcinoma of the vulva. Expression of tumor proteases cathepsin-D and pro-cathepsin-L. 1998
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28: Immunohistochemical localization of cathepsins D and E in human gastric cancer: a possible correlation with local invasive and metastatic activities of carcinoma cells. 1996
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29:Cathepsins D, B, and L in malignant human lung tissue. 1996
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30:Cathepsin B and cysteine proteinase inhibitors in bronchoalveolar lavage fluid of lung cancer patients. 1993
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31: Inflammatory breast carcinoma: an immunohistochemical study using monoclonal anti-pHER-2/neu, pS2, cathepsin, ER and PR. 1992
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32:Cathepsins D and E in normal, metaplastic, dysplastic, and carcinomatous gastric tissue: an immunohistochemical study. 1990
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33: Enzymatically active cathepsin B dissociating from its inhibitor complexes is elevated in blood plasma of patients with septic shock and some malignant tumors. 1988
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34: [Kininogenase activity of cathepsins D] 1980
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http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi



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