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Cell:
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
Highlights:
Neutrophils undergo a process of aging during their lifetime in circulation
Neutrophil clearance reduces the size and function of the hematopoietic niche
Macrophages and LXR receptors mediate changes in the niche
Neutrophil clearance triggers rhythmic release of progenitors during homeostasis
Immunity:
A Clonogenic Progenitor with Prominent Plasmacytoid Dendritic Cell Developmental Potential
Highlights
The redefined CDPs include E2-2loM-CSFR+ and E2-2hiM-CFSR cells
E2-2hiM-CSFR CDPs show prominent pDC differentiation potential
E2-2hiM-CSFR CDPs might be derived from either E2-2loM-CSFR+ CDPs or LMPPs
M-CSF and TPO upregulate E2-2 expression in the CDPs
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