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重组热点相关文献

已有 5444 次阅读 2011-11-28 09:16 |个人分类:未分类|系统分类:科研笔记| div, quot, amp

这是个让人感兴趣的主题.可以这样理解,重组并不完全是随机的,重组热点和重组冷点的存在是破坏这种随机性的直接原因.为什么有的位点会成为热点,而有的又是冷点,这背后的机制是什么.是不是能把任意位点变成重组热点或者冷点.既然有hotspot motif,但好象看起来也是可能的.

这不属于我的主要研究领域,但多学点知识应该没什么坏处.文章还没细读,能记住这里有这样几篇文章,可能才是要点.

Wahls, W.P., and Davidson, M.K. DNA Sequence-Mediated, Evolutionarily Rapid Redistribution of Meiotic Recombination Hotspots. Genetics 189, 685-694.

DNA Sequence-Mediated, Evolutionarily Rapid.pdf

Baudat, F., Buard, J., Grey, C., Fledel-Alon, A., Ober, C., Przeworski, M., Coop, G., and de Massy, B. PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice. Science 327, 836-840.

PRDM9 Is a Major Determinant of Meiotic.pdf
Cheung, V.G., Sherman, S.L., and Feingold, E. Genetic Control of Hotspots. Science 327, 791-792.
Myers, S., Bowden, R., Tumian, A., Bontrop, R.E., Freeman, C., MacFie, T.S., McVean, G., and Donnelly, P. Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination. Science 327, 876-879.

Drive Against Hotspot Motifs in Primates Implicates.pdf
Parvanov, E.D., Petkov, P.M., and Paigen, K. Prdm9 Controls Activation of Mammalian Recombination Hotspots. Science 327, 835-.

Prdm9 Controls Activation of.pdf

The Case of the Fickle Fingers: How the PRDM9 Zinc Finger Protein Specifies Meiotic Recombination Hotspots
in Humans

The Case of the Fickle Fingers How the PRDM9 Zinc Finger Protein Specifies Meiot.pdf

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