对水稻来说,单个基因控制性状的研究已经是件很常规的事了.当然这得有合适的材料,也就是突变体.水稻中现在已经有非常多的突变体了,T-DNA插入突变,TOS17插入突变,Ac/Ds系统插入突变,EMS诱变,射线诱变.所以,基于突变体的研究不是什么难事.难点还是在由多个QTL控制的性状也就是数量性状,如果对数量性状认识比较深刻,研究起来可能更加容易些,当然这需要学习,需要踩在巨人的肩上这样才能站得高,望得远.巨人在哪?不是道听徒说,现在的巨人一般都要用文章来证明他的巨大,所以得看文章,如果来不及看,至少应该记得有这样一篇文章,需要的时候能够想起来

The genetics of quantitative traits: challenges and prospects.NATURE Reiews  Genetics(期刊名足以保证它的可读性和可信性),2009

genetics of quantitative traits

    这篇综述的主题有:

              QTL  mapping(QTL作图),

              Genetic architecture: lessons learned(遗传构成,这个主题下又有以下几个方面Many loci with small effects,Novel loci,这个有点类似于主效QTL,作者可能是人类或动物遗传学背景.Context-dependent effects.其实就是考虑互作,包括基因间的互作,基因和环境的互作等.Pleiotropy,多效性;Molecular basis of quantitative variation.)

              Genetic architecture: challenges(遗传构成,难点)

               The genetic dissection of quantitative traits faces two main challenges: the power to detect and localize QTLs and QTNs, and the biological context in which to place genotype–phenotype associations.

 

相似的主题,如果是2002年写的会有很大的不同

        UNDERSTANDING QUANTITATIVE GENETIC VARIATION

UNDERSTANDING QUANTITATIVE

        这篇文章的背景:Until recently, it was impracticable to identify the genes that are responsible for variation
in continuous traits, or to directly observe the effects of their different alleles. Now, the abundance of genetic markers has made it possible to identify quantitative trait loci (QTL) —the regions of a chromosome or, ideally, individual sequence variants that are responsible for trait variation.刚开始克隆QTL的时代.现在水稻中已经克隆了多个QTL了.

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