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1. DAVID HAUSSLER 教授绝对是生物信息学里的实力派,现在Pubmed里的基因数据库早已空心化,原来的The Johns Hopkins的数据库倒了,美国的基因数据库重 点现在都转到了UCSC Genome Browser上了。(http://genome.ucsc.edu/),这是翰森(HAUSSLER)教授领导的研究所和数据库,熟悉这个数据库的人 都知道它的功能非常强大,比Pubmed好用的多。翰森教授也是休斯医学研究所的研究员。美国科学院,艺术科学院双院院士。翰森教授最主要的贡献是著名的海得-马克吾模型(HMMs)建立的开拓者,这个模型被广泛用于分析DNA,RNA和单白质的序列分析上, 是近代生物信息学中的基本模型之一。
Investigator, Howard Hughes Medical Institute
Distinguished Professor, Biomolecular Engineering, University of California,Santa Cruz
Director, Center for Biomolecular Science and Engineering
He is a member of the National Academy of Sciences and the American Academy of Arts
and Sciences and a fellow of AAAS and AAAI. He has won a number of awards, including
the 2006 Dickson Prize for Science from Carnegie Mellon University and the 2003 ACM/ AAAI
Allen Newell Award.
主要代表性文章:
(1) Nature Methods. 2009 Apr;6(4):239-40.
(2) Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14254-61.
(3) Science. 2007 Aug 17;317(5840):915.
(4) Proc Natl Acad Sci USA. 2007 Nov 20;104(47):18613-8.
(5) Nature. 2007 Nov 8;450(7167):219-32.
2. 犹太美女科学家-艾薇,现为哈佛-麻省理工的博德研究所的(助教授),Aviv Regev真的太牛了,Ph.D.只是在以色列读的,在哈佛做了几年Fellow就成了Broad/Whitehead研究所里的物信息学的明星,当然这跟哈佛MIT强大的犹太科学家关系网的扶持有关,超级牛人 Eric Lander所长很明显是喜欢Aviv的。今年Aviv(艾薇)博士双喜临门,刚刚和DAVID HAUSSLER获得了国际计算协会的大奖之一--青年创新奖,又被休斯医学研究所选为新科入门级的研究员,休斯医学研究所将给她支付未来6年里的研究室场地,人员, 工资和主要设备费用和150万美元的科研经费。
艾薇博士的主要贡献是创造性的开发出了抽象代数记算计语言来整合复杂多样的生物数据,如分子机理,信号传导途径和代谢合成路径。从而使我们能够用计算机更好的处理复杂多样和连锁的生物数据。
Aviv was recently awarded the Burroughs Wellcome Fund Career Award at the
Scientific Interface to support her research on the function and evolution
of molecular networks. In addition to her position at the Broad Institute,
she is an assistant professor in the Department of Biology at MIT.
主要代表性文章:
(1)Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3264-9.
(2)Nature. 2009 Mar 12;458(7235):223-7.
(3)Cell. 2007 Nov 2;131(3):544-56.
(4)Nature. 2007 Sep 6;449(7158):54-61.
(5)Nat Genet. 2004 Oct;36(10):1090-8.
Each year, the International Society for Computational Biology (ISCB; http://www.iscb.org) gives two
major awards to leaders and innovators in the field of bioinformatics. The awards committee, composed
of current and past directors of the Society and previous award winners, has announced that the 2008
Accomplishment by a Senior Scientist Award will be given to David Haussler of the University of California
Santa Cruz, Santa Cruz, California, United States, and the 2008 Overton Prize for outstanding achievement
in early to midde career will be awarded to Aviv Regev of MIT and the Broad Institute of MIT and Harvard,
Cambridge, Massachusetts, United States. Both award winners are Associate Editors for PLoS Computational
Biology, an official journal of ISCB.
3. Claire M. Fraser-Ligget 克莱尔博士,很多人都知道是生物超人Craig Venter温特博士的前妻,曾经和温特博士一起建立了第一家私立的基因研究所(TIGR),开创性的采用随机高速基因组测序,再将数据用计算计拼装的划时代测序战略,挑战并赢得了与全世界所有大学里 当时采用的经典的先用BAC, YAC等克隆分装基因组片段,再进行测序的传统手段!开创了从微生物(噬血杆菌基因组测序)到人的全基因组测序的突破!
克莱尔博士后来又领导主挑完成首个人类基因组测序的工作的Venter研究所,成为全世界最有成就的100位女科学家,在微生物学和基因组学上有巨大的贡献。现为马里兰大学基因组研究所所长。
主要代表性文章:
(1)Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science. 2009 Apr 3;324(5923):55-9.
(2)Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature. 2008 Oct 9;455(7214):757-63
(3)The human microbiome project. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. Nature. 2007 Oct 18;449(7164):804-10
(4)Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science. 2007 Jan 12;315(5809):207-12.
(5)Global genetic population structure of Bacillus anthracis. PLoS ONE. 2007 May 23;2(5):e461.
PLoS ONE. 2007 May 23;2(5):e461.
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