2024年10月5日，Elsevier 旗下top期刊《Food Chemistry》在线发表了云南师范大学化学与化工学院胡蓉教授课题组最新研究成果《Smartphone-based dual-mode aptasensor with bifunctional metal-organic frameworks as signal probes for ochratoxin A detection》。云南师范大学化学化工学院胡蓉教授为通讯作者。

https://www.sciencedirect.com/science/article/abs/pii/S030881462403190X

Abstract

Ochratoxin A (OTA) poses significant risks to human health, being potentially nephrotoxic, carcinogenic, genotoxic, and immuno-toxic. In this work, we developed a dual-mode aptasensor for OTA analysis, integrating colorimetric, electrochemical, and smartphone-based detection. The bifunctional Fe-MIL-88 metal-organic framework, acting as both a nanozyme capable of catalyzing the 3,3′,5,5′-tetramethylbenzidine substrate and an electrochemical signal amplifier, enabled OTA quantification through current response or changes in color and absorbance intensity. Besides, the spatial confinement effect enhances the local concentration of Fe-MIL-88 signal probes through rolling circle amplification reaction, thereby contributing to a substantial enhancement in sensitivity. The proposed technique is simple, disposable, highly sensitive and selective, enabling OTA detection in the range of 1 fg/mL to 250 ng/mL, with a limit of detection of 0.22 fg/mL (3σ rule). Furthermore, we successfully detected OTA in corn, wheat, and red wine samples, with results good concordance with those obtained using commercial enzyme-linked immunoassay kits.

拓展阅读：

云师大化工学院胡蓉教授和杨通副教授在top期刊《Chemical Science》发表最新研究成果

云师大化工学院胡蓉教授课题组在top期刊《Food Chemistry》发表最新研究成果

云师大化工学院胡蓉教授课题组在top期刊《Talanta》发表最新研究成果

云南师范大学胡蓉团队在美国食品化学《FOOD CHEMISTRY》发表最新研究成果

云师大化工学院胡蓉博士最新研究成果在ACS Applied Materials & Interfaces上刊登

云师大胡蓉博士在《Biosensors and Bioelectronics》上刊文

云南师范大学生物电分析领域中青年学者之 胡蓉

云师大化工学院杨通博士在top期刊《Biosensors and Bioelectronics》发表最新研究成果

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