α-Cyano-4-hydroxycinnamic acid | α-氰基-4-羟基肉桂酸

MCE 国际站：α-Cyano-4-hydroxycinnamic acid

中文名：α-氰基-4-羟基肉桂酸

CAS：28166-41-8

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) 是一种有效的非竞争性单羧酸转运蛋白 (MCT) 抑制剂。 α-Cyano-4-hydroxycinnamic acid 抑制线粒体丙酮酸转运蛋白，K_i 为 6.3 μM。 α-Cyano-4-hydroxycinnamic acid 在基质辅助激光解吸/电离飞行时间 (MALDI-TOF) 质谱应用中用作促进肽电离的基质^[1][2]。  

体外：α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) 抑制单羧酸转运，例如乳酸和丙酮酸^[2]。1 mM 的 α-Cyano-4-hydroxycinnamic acid（CHC；0.5 mM 和 1 mM）对分支形态发生有显着抑制作用，并以剂量依赖的方式减少肺外植体的上皮周长和面积 ^[2].在 100 μM 浓度下，α-Cyano-4-hydroxycinnamic acid 迅速且几乎完全抑制大鼠心脏线粒体氧化丙酮酸盐对 O₂ 的摄取。在低至 1 μM 的抑制剂浓度下可以检测到抑制作用，尽管在此浓度下抑制作用需要时间才能形成。可以通过稀释抑制剂^[1] 来逆转抑制。

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研究领域：Membrane Transporter/Ion Channel

作用靶点：Monocarboxylate Transporter

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参考文献：[1]. A P Halestrap, et al. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975 Apr; 148(1): 85-96.

[2]. Sara Granja, et al. The Monocarboxylate Transporter Inhibitor α-cyano-4-hydroxycinnamic Acid Disrupts Rat Lung Branching. Cell Physiol Biochem. 2013;32(6):1845-56.

[3]. Makoto Watanabe, et al. Improvement of Mass Spectrometry Analysis of Glycoproteins by MALDI-MS Using 3-aminoquinoline/α-cyano-4-hydroxycinnamic Acid. Anal Bioanal Chem. 2013 May;405(12):4289-93.