Amlitelimab

MCE 国际站：Amlitelimab

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：Alvircept sudotox 是一种抗 OX40 配体 (OX40L) 单克隆抗体 (mAb)。Alvircept sudotox 抑制 OX40-OX40L 相互作用，可用于特应性皮炎的研究。

体外：Amlitelimab (150 μg/mL) inhibits proliferation of human CD3 T cells[3]. Amlitelimab (150 μg/mL) 抑制人 CD3 T 细胞的增殖[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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研究领域：Others

作用靶点：Others

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参考文献：[1]. Ana Maria Lé, et al. OX40-OX40L Inhibition for the Treatment of Atopic Dermatitis-Focus on Rocatinlimab and Amlitelimab. Pharmaceutics 2022, 14(12), 2753. 

[2]. Saghari M, et al. OX40L Inhibition Suppresses KLH-driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof-of-Pharmacology for KY1005. Clin Pharmacol Ther. 2022 May;111(5):1121-1132. 

[3]. Tkachev V, et al. Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant. Sci Transl Med. 2017 Sep 20;9(408):eaan3085.