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MCE 国际站:Demethylzeylasteral
中文名:去甲泽拉木醛
CAS:107316-88-1
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Demethylzeylasteral 是一种从 Tripterygium wilfordii Hook F 中分离出来的三萜化合物,具有抗炎、免疫抑制和抗肿瘤活性[1][2] [3][4][5]。 Demethylzeylasteral 可显着缓解动脉粥样硬化 (AS)[5]。 Demethylzeylasteral 通过阻断经典和非经典 TGF-β 信号通路抑制三阴性乳腺癌侵袭[2]。
热销产品:Exatecan (mesylate) | MRTX1133 | Cetuximab | MG-132 | SBE-β-CD | Rapamycin | Tamoxifen | Olaparib | Sotorasib | Eribulin (mesylate)
研究领域:Apoptosis
作用靶点:Apoptosis
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Wang Q, et al. Demethylzeylasteral ameliorates inflammation in a rat model of unilateral ureteral obstruction through inhibiting activation of the NF‑κB pathway. Mol Med Rep. 2017 Jul;16(1):373-379.
[2]. Zhao Y, et al. Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells. Cell Death Dis. 2017 Oct 26;8(10):e3133.
[3]. Experimental study of the anti-atherosclerotic effect of demethylzeylasteral. Exp Ther Med. 2017 Jun;13(6):2787-2792.
[4]. Zhang K, et al. Demethylzeylasteral inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis. Cell Death Dis. 2018 Oct 10;9(10):1035.
[5]. Li L, et al. Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways. Naunyn Schmiedebergs Arch Pharmacol. 2019 May;392(5):593-603.
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