Peimisine

国际站：Peimisine

中文名：贝母辛

CAS：19773-24-1

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Peimisine (Ebeiensine) 是一种毒蕈碱型 M 受体拮抗剂和血管紧张素转化酶 (ACE) 抑制剂。 Peimisine 具有抗肿瘤、抗炎、抗高血压活性。 Peimisine可诱导细胞凋亡，用于咳喘研究^[1][2][3]。 

体外：Peimisine (17.43-92.07 μg/mL; 72 h)显示出显着的细胞毒性作用^[3]。Peimisine (15 μg/mL; 24、48和72 h)诱导G ₀/G₁期阻滞和细胞凋亡率上升^[3]。

参考文献：[1]. Pan F, et al. Peimisine and peiminine production by endophytic fungus Fusarium sp. isolated from Fritillaria unibracteata var. wabensis. Phytomedicine. 2014 Jul-Aug;21(8-9):1104-9.[2]. Armando Alberola-Die, et al. Peimine, an Anti-Inflammatory Compound from Chinese Herbal Extracts, Modulates Muscle-Type Nicotinic Receptors. Int J Mol Sci. 2021 Oct 19;22(20):11287.[3]. Dongdong Wang, et al. Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action. BMC Complement Altern Med. 2015 Feb 21;15:29.