Nervonic acid

国际站：Nervonic acid

中文名：神经酸

CAS：506-37-6

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性：神经酸是一种单不饱和脂肪酸，在髓磷脂的生物合成中很重要。

体外：Nervonic acid (0.01 μM, 48 h) 可提高 PC-12 细胞活力，在大脑中发挥神经保护介质的作用[1]。 Nervonic acid (12.5, 25, 50 μM, 24 h ) 可降低 LPS 诱导的 RAW264.7 细胞的炎症反应，抑制炎症相关关键信号通路的激活[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Nervonic acid (20, 40, 60 mg/kg, 灌胃, 7 天) 在 PD 小鼠模型中保护运动系统免受运动障碍[2]。 Nervonic acid (5, 50, 100 mg/kg, 溶解在玉米油中灌胃，7 天) 通过抑制 DSS 诱导结肠炎小鼠 NF-κB 信号通路改善结肠炎症[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MPTP-induced PD mice model[2] Dosage: 20, 40, 60 mg/kg Administration: i.g. Result: Reversed behavioral deficits inhibited the α-synuclein expression and regulated oxidative stress response. Animal Model: DSS-induced colitis mice model[3] Dosage: 5, 50, 100 mg/kg Administration: i.g. Result: Improved the symptoms of diarrhea, weight loss and fecal occidental blood. Reduced the levels of COX-2 and iNOS.

参考文献：[1]. Amminger GP, et al. Decreased nervonic acid levels in erythrocyte membranes predict psychosis in help-seekingultra-high-risk individuals. Mol Psychiatry. 2012 Dec;17(12):1150-2.