Hyocholic Acid

国际站：Hyocholic Acid

CAS：547-75-1

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：Hyocholic Acid 是一种最早在猪体内发现的胆汁酸。Hyocholic Acid 也可以在胆汁淤积患者的尿液样本中发现。Hyocholic Acid 通过激活 TGR5 和抑制 FXR 促进肠内分泌细胞 GLP-1 分泌。Hyocholic Acid 可抵抗 2 型糖尿病。

体外：HCA (25 and 50 μM, 24 h) upregulates GLP-1 protein secretion in STC-1 and NCI-H716 cells[3]. HCA (25 and 50 μM, 24 h) upregulates proglucagon gene transcription in STC-1 and NCI-H716 cells[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs[3]. Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BA depletion pigs[3] Dosage: 20 mg/kg Administration: Oral administration (p.o.) Result: Attenuated the increased blood glucose levels corresponding with GLP-1 decrease. Animal Model: db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model[3] Dosage: 100 mg/kg/day Administration: Oral administration (p.o.) Result: Improved oral glucose tolerances shown by lower glucose levels. Increased circulating active GLP-1 levels and fasting insulin levels.

参考文献：[1]. Zheng X, et al. Hyocholic acid species as novel biomarkers for metabolic disorders. Nat Commun. 2021 Mar 5;12(1):1487.[2]. van Berge Henegouwen, et al. Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut 17(11), 861-869 (1976).[3]. Xiaojiao Zheng, et al. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metab. 2021 Apr 6;33(4):791-803.e7.