Chlorin e6

国际站：Chlorin e6

CAS：19660-77-6

品牌：MedChemExpress (MCE)

存储条件：-20°C, protect from light

生物活性： Chlorin e6 是一种光敏剂。当存在于含胰岛素的偶联物中时，二氢卟酚 e6 具有显着高的光敏活性，因此能够被表达受体的细胞内化。 Chlorin E6 影响Leishmania major 和Leishmania braziliensis 前鞭毛体^[1][2] 的活力和线粒体活性。

体外：Chlorin e6 (100 μg/mL, 24 h) 在 635 nm 激光照射下对 HT-29 细胞中没有毒性[2]。 Chlorin e6 (5-10 μM, 3 h) 在 660 nm 近红外激光照射下通过激活 caspase-3 诱导胰腺癌细胞凋亡，从而抑制 AsPC-1 和 MIA PaCa-2 细胞的肿瘤生长[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Chlorin e6 (2.5 mg/kg，静脉注射，单次剂量) 以 100 J/cm2 的红光照射 8 min 20 s 在 B16F10 黑色素瘤细胞和 PANC02 胰腺细胞异种移植小鼠模型中具有抗肿瘤活性[3]。 Chlorin e6 (2.5 mg/kg，静脉注射，单次剂量) 在 660 nm 近红外激光照射下可抑制犬肿瘤生长[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: B16F10 melanoma cells xenograft mouse, PANC02 pancreatic cells xenograft mouse[3] Dosage: 2.5 mg/kg Administration: Intravenous injection (i.v.) Result: Significantly reduced tumor volume.

参考文献：[1]. Nie M, et al. Photodynamic inactivation mediated by methylene blue or chlorin e6 against Streptococcus mutans biofilm [J]. Photodiagnosis and photodynamic therapy, 2020, 31: 101817.[2]. Karuppusamy S, et al. Nanoengineered chlorin e6 conjugated with hydrogel for photodynamic therapy on cancer [J]. Colloids and Surfaces B: Biointerfaces, 2019, 181: 778-788.[3]. Shrestha R, et al. Effect of Photodynamic Therapy with Chlorin e6 on Canine Tumors [J]. Life, 2022, 12(12): 2102.