|
国际站:Thymidine
中文名:胸苷
CAS:50-89-5
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:胸苷是脱氧核糖核酸的特定前体,用作细胞同步化剂。胸苷是一种 DNA 合成 抑制剂,可在 DNA 复制之前将细胞停滞在 G1/S 边界[1][2] [3]. IC50 和目标:DNA 合成[2] 。
体内:胸苷(500 mg/kg;腹腔注射;每天两次)完全逆转甲氨蝶呤和 Tomudex 诱导的 CD4+Vβ8+ 和 CD8+< 缺失/sup>Vβ8+ T 细胞 [3]。
参考文献:[1]. Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8(17).[2]. FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4604):274-5.FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4604):274-5.[3]. Izeradjene K, et al. Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independentdeletion of superantigen-reactive peripheral T cells. Int Immunol. 2001 Jan;13(1):85-93.
Archiver|手机版|科学网 ( 京ICP备07017567号-12 )
GMT+8, 2024-9-26 12:19
Powered by ScienceNet.cn
Copyright © 2007- 中国科学报社