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国际站:α-MSH | α-黑素细胞刺激激素 (MSH),酰胺
CAS:581-05-5
品牌:MedChemExpress (MCE)
存储条件:Powder: -80°C, 2 years; -20°C, 1 year.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:α-MSH (α-Melanocyte-Stimulating Hormone) 是一种内源性神经肽,是一种内源性 黑皮质素受体 4 (MC4R) 激动剂,具有抗炎和解热活性。 α-MSH 是阿黑皮素原 (POMC)[1][2] 的翻译后衍生物。 IC50 和靶标:MC4R[2]
体外:α-MSH 通过直接作用于神经胶质细胞中的黑皮质素受体来调节 CNS 炎症。 α-MSH 调节 NFκB 激活。 α-MSH 抑制转录因子 κB 转运至细胞核[3]。
体内:全身给予 α-MSH(50 µg/0.2 ml 生理盐水;ip)可有效调节炎症反应[3]。
参考文献:[1]. Madhuri Singh, et al. C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May;55(5):1920-9.[2]. M S Kim, et al. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes. 2000 Feb;49(2):177-82.[3]. Lipton JM, et al. Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence. Ann N Y Acad Sci. 1999;885:173-182.
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