中文名：麦角硫因

国际站：Ergothioneine | 麦角硫因

CAS：497-30-3

品牌：MedChemExpress (MCE)

存储条件：-20°C, sealed storage, away from moisture

生物活性：麦角硫因是组氨酸甜菜碱的咪唑-2-硫酮衍生物，由某些细菌和真菌合成。麦角硫因通常被认为是一种抗氧化剂^[1]。

体外：Ergothioneine (0.25, 1 mM, 23 h) 对过氧化氢诱导的 PC12 DNA 损伤、MAPKs 激活和细胞死亡有调节作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Ergothioneine (70 mg/kg, 口服, 连续 14 天) 在大鼠中通过调节 Nrf2、p53 和 NF-κB 信号和抑制 γ-谷氨酰转肽酶介导顺铂引起的肾毒性的改善作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Cisplatin-treated rats[1] Dosage: 70 mg/kg Administration: p.o. Result: Decreased serum creatinine and BUN. Increased GFR at two-fold. Suppressed cisplatin-induced oxidative stress and GCT. Up-regulated the levels of Nrf2, NQO1, and HO-1. Suppresses NF-κB signaling and the pro-inflammatory cytokines. Clinical Trial

参考文献：

[1]. Oumari M, et al. Regeneration of ergothioneine after reaction with singlet oxygen. Free Radic Biol Med. 2019 Apr;134:498-504.