本组拟招聘药物化学/化学生物学专业背景的高级助手1人，具体要求见下文广告。
希望申请人已有北京户口，有工作经验（原则上不招聘应届生或博后）。如果没有北京市户口，可通过博后岗位过渡。
Research scientist
Institute of Materia Medica, Chinese Academy of Medical Sciences
A research scientist position is currently available in Fang lab (www.imm.ac.cn/groups/fangws/), Institute of Materia Medica, Chinese Academy of Medical Sciences (IMM, CAMS).
We focus on Medicinal Chemistry and Chemical Biology of Bioactive Natural Products, and take a multidisciplinary approach to the discovery of novel therapeutic agents for cancer and metabolic diseases.
We also strive to translate the knowledge gained in the basic research into the discovery of new drug target and relevant bioactive molecules. Recent research projects are focused on selective antitumor agent discovery and tumor-targeting delivery, including targeting of microtubule (MT), microtubule associated protein (MAP) and MT-MAP protein-protein interactions, as well as the synthesis of macrocycles-based natural products and designed compounds.
Major Responsibilities:
- Contribute to ligand-based and structure-based design, and hit to lead and lead optimization.
- Synthesize, purify and characterize biologically active compounds.
- Develop new synthetic approaches to novel small molecules.
- Understand biological results, summarize SAR and propose additional modifications.
- Contribute to scientific paper and patent preparation, and get involved in research grant competition.
- Assist PI to supervise, coach and motivate junior scientists and graduate students.
Requirements:
- Ph.D. in synthetic medicinal chemistry, chemical biology, or relevant fields, with 3+ year’s working experience.
- Passion for drug discovery and genuine curiosity for novel approaches to improve the drug discovery approach and generate better clinical candidates.
- Solid understanding of modern structure determination methods and separation techniques, and fundamental understanding of organic reaction mechanisms.
- Proficient in SAR elucidation in drug discovery including hit to lead and lead optimization.
- Knowledgeable in cutting edge medicinal chemistry platforms.
- Demonstrated understanding of ADMET parameters and pharmacokinetic principles and their application to solve problems in drug discovery.
- Excellent verbal and written communication skills.
Preferred expertise:
- Hands on experience in molecular modelling, preferably using Discovery Studio softwares.
- Proficient in manipulating analytical and preparative chromatographic instruments (e.g., HPLC and/or LC-MS).
- Demonstrated ability in delivering compounds to preclinical or clinical development is a plus.
Application:
Interested applicants should send an application package in one pdf including: cover letter to demonstrate your fit for this position, curriculum vitae, research summary with an emphasis on your most significant contributions, 2-3 representative publications (pdf), and 3 references' contact information, to Dr. Weishuo Fang (wfang .AT. imm.ac.cn, please change .AT. to @ when sending your email).
About IMM, CAMS
Institute of Materia Medica, Chinese Academy of Medical Sciences, is a non-profit organization with the mission to development new pharmaceutical agents against various acute and chronic diseases.
For more information, please go to the website: www.imm.ac.cn/cn/index.asp (Chinese); www.imm.ac.cn/en/index.asp (English).
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