Nature——微观结构学研究揭示突触囊泡融合的神经分子机制

Summary

1. Crystal structures of the Syt1–SNARE–Cpx–Syt1 complex.

2. Close-up views of the SNARE–Cpx–Syt1 tripartite interface.

3. Probing the interfaces between the SNARE complex and the Syt1 C2B domain by ITC.

4. Ca2+ triggering of release by Syt1 requires both the SNARE–Cpx–Syt1 and the Syt1–SNARE interfaces.

5. Unlocking and triggering the primed Syt1–SNARE–Cpx–Syt1 complex.