|||
Nature neurosci——PD-L1通过PD-1抑制急慢性疼痛
Nature neurosci—PD-L1通过PD-1抑制急慢性疼痛
1.Exogenous PD-L1 inhibits formalin-induced inflammatory pain and increases pain threshold in naive mice.
2.Endogenous PD-L1 regulates pain sensitivity in naive mice via PD-1.
3.PD-1 is expressed by mouse DRG neurons and nerve axons.
4.PD-L1 suppresses neuronal excitability in mouse DRG neurons via PD-1.
5.PD-L1 inhibits neuronal hyperexcitability and neuropathic pain after nerve injury.
6.PD-L1 modulates neuronal excitability and pain via SHP-1.
7.PD-L1 suppresses action potential firing and sodium currents and regulates RMP in human DRG neurons.
8.Blocking of PD-L1 or PD-1 signaling induces spontaneous pain and allodynia in a mouse melanoma model.
经典文章回顾
你对老年性痴呆症到底懂多少?
喜欢我,关注我
拉到最上方标题下,点击上方蓝字关注
搜索公众号名称:神经科学临床和基础
也请你推荐给你身边的医学朋友,感谢你~
Archiver|手机版|科学网 ( 京ICP备07017567号-12 )
GMT+8, 2024-5-29 17:08
Powered by ScienceNet.cn
Copyright © 2007- 中国科学报社