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2011年Cell和Nature Medicine上两篇关于屠呦呦工作的文章

已有 3908 次阅读 2015-10-6 19:51 |系统分类:论文交流

据说,屠呦呦得诺贝尔奖与两位美国科学家的推荐有关,分别是Louis H. Miller和Xinzhuan Su。文中说二人于2010年开始推荐屠呦呦到诺贝尔奖和拉斯克奖,并在得到拉斯克奖认可后在Cell发表了一篇介绍屠呦呦的文章。Cell的影响因子和影响力使得屠呦呦广为人知。那么这篇论文到底写了什么呢?


Cell期刊在146卷第6期,2011年9月16日,第855页到858页,发表了论文“Artemisinin: Discovery from the Chinese Herbal Garden”,作者为Louis H. Miller和Xinzhuan Su(doi:10.1016/j.cell.2011.08.024)。论文内容如下:


Artemisinin: Discovery from the Chinese Herbal Garden

This year's Lasker DeBakey Clinical Research Award goes to Youyou Tu for the discovery of artemisinin and its use in the treatment of malaria—a medical advance that has saved millions of lives across the globe, especially in the developing world.

Main Text

The future benefits of many seminal discoveries in basic biomedical sciences are not always obvious in the short run. But for a handful of others, the impact on human health is immediately clear. Such is the case for the discovery by Youyou Tu and colleagues of artemisinin (also known as Qinghaosu) for treatment of malaria. Artemisinin has been the frontline treatment since the late 1990s and has saved countless lives, especially among the world's poorest children.

The Promise of Project 523

The story of artemisinin began in the unlikely atmosphere of the Cultural Revolution in China as a government initiative to aid the North Vietnamese in their war with the United States. During the war, malaria caused by chloroquine-resistant Plasmodium falciparumwas a major problem that spurred research efforts on both sides of the battlefield. In the US, these efforts culminated in the discovery of mefloquine, a compound that was curative in a single dose against chloroquine-resistant parasites ( Trenholme et al., 1975). The North Vietnamese, however, lacked a research infrastructure and thus turned to China for help.

……(该文章为开放获取,论文全文见网页:http://www.sciencedirect.com/science/article/pii/S0092867411009500


另外,Google Scholar检索发现屠呦呦于2011年10月11日在Nature Medicine上发表了一篇介绍其工作的文章,被引次数为128次。该论文正文中的图片有一张伟中国古籍的照片,正是颁发诺贝尔奖的PPT上所用到的照片。另外,论文中海油当时工作团队的大合影。doi:10.1038/nm.2471。论文内容如下:

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

Nature Medicine17, 1217–1220 (2011) doi:10.1038/nm.2471Published online 11 October 2011


Joseph Goldstein has written in this journal that creation (through invention) and revelation (through discovery) are two different routes to advancement in the biomedical sciences1. In my work as a phytochemist, particularly during the period from the late 1960s to the 1980s, I have been fortunate enough to travel both routes.

I graduated from the Beijing Medical University School of Pharmacy in 1955. Since then, I have been involved in research on Chinese herbal medicine in the China Academy of Chinese Medical Sciences (previously known as the Academy of Traditional Chinese Medicine). From 1959 to 1962, I was released from work to participate in a training course in Chinese medicine that was especially designed for professionals with backgrounds in Western medicine. The 2.5-year training guided me to the wonderful treasure to be found in Chinese medicine and toward understanding the beauty in the philosophical thinking that underlies a holistic view of human beings and the universe.

Discovery of antimalarial effect of qinghao

Malaria, caused by Plasmodium falciparum, has been a life-threatening disease for thousands of years. After the failure of international attempts to eradicate malaria in the 1950s, the disease rebounded, largely due to the emergence of parasites resistant to the existing antimalarial drugs of the time, such as chloroquine. This created an urgent need for new antimalarial medicines. In 1967, a national project against malaria was set up in China under the leadership of the Project 523 office. My institute quickly became involved in the project and appointed me to be the head of a malaria research group comprising both phytochemical and pharmacological researchers. Our group of young investigators started working on the extraction and isolation of constituents with possible antimalarial activities from Chinese herbal materials.

……(论文全文见网页:http://www.nature.com/nm/journal/v17/n10/full/nm.2471.html


这两篇论文,一篇发表在影响因子32.242的Cell上,一篇发表在影响因子27.363的Nature Medicine上,这两篇论文弥补了屠呦呦过去没有发表SCI论文的缺失,是诺贝尔奖委员会和世人了解其工作的主要参考文献。


参考资料:揭秘屠呦呦美国推荐人:2010年起年年推荐(http://news.sciencenet.cn/htmlnews/2015/10/328133.shtm



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