Cell:

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

• Highlights:

• Neutrophils undergo a process of aging during their lifetime in circulation

• Neutrophil clearance reduces the size and function of the hematopoietic niche

• Macrophages and LXR receptors mediate changes in the niche

• Neutrophil clearance triggers rhythmic release of progenitors during homeostasis

Immunity:

A Clonogenic Progenitor with Prominent Plasmacytoid Dendritic Cell Developmental Potential

• Highlights

• The redefined CDPs include E2-2^loM-CSFR⁺ and E2-2^hiM-CFSR cells

• E2-2^hiM-CSFR CDPs show prominent pDC differentiation potential

• E2-2^hiM-CSFR CDPs might be derived from either E2-2^loM-CSFR⁺ CDPs or LMPPs

• M-CSF and TPO upregulate E2-2 expression in the CDPs