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GWAS-----全基因组关联分析

已有 11195 次阅读 2010-11-12 17:28 |个人分类:未分类|系统分类:科研笔记| 基因组, 拟南芥

        GWAS在人类疾病的研究中非常热门,但是在动植物的研究中却刚刚开始起步,正处在向人类GWAS方面进行借鉴的过程。但是GWAS对于动植物的研究可能将更加具有优势。由于动植物不像人类那样可以随意构建群体以及随意重组。以下是到现今在动植物方面的gwas研究paper!

目前在动植物中应用到GWAS已经报道的物种包括拟南芥、小鼠、果蝇、水稻、牛、狗、猪。 
拟南芥:
Genome-Wide Association Mapping in Arabidopsis Identifies Previously Known Flowering Time and Pathogen Resistance Genes. 2005 PLoS genetics
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines.
2010 nature
 
小鼠:
Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease. 2002 nature genetics
 
果蝇:
Genome-wide analysis of a long-term evolution experiment with Drosophila . 2010 nature
 
水稻:
Genome-wide association studies of 14 agronomic traits in rice landraces. 2010 nature genetics
 
牛:
A Validated Genome Wide Association Study to Breed Cattle Adapted to an Environment Altered by Climate Change. 2009 PLoS One
A validated genome-wide association study in 2 dairy cattle breeds for milk production and fertility traits using variable length haplotypes. 2009 Journal of Dairy Science
 
Genome-wide association study of growth in crossbred beef cattle. 2010 Journal Animal Science
 
Two-stage genome-wide association study identifies integrin beta 5 as having potential role in bull fertility. 2009 BMC genomics
 
狗:
Genome-wide association analysis of canine atopic dermatitis and identification of disease related SNPs. 2009 Immunogenetics
 
Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. 2010 nature genetics
 
Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. 2009 PNAS
 
猪:
A genome-wide association study on androstenone levels in pigs reveals a cluster of candidate genes on chromosome 6. 2010 BMC genetics
 

玉米:

Genome-wide association study of quantitative resistance to southern leaf blight in the maize nested association mapping population.2010 Nature genetics

Genome-wide association study of leaf architecture in the maize nested association mapping population.2010 Nature genetics



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