氢水治疗疾病饥饿素机制研究学者野田百美

Email: noda@phar.kyushu-u.ac.jp

Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

九州大学药学院野田百美教授Mami Noda, Kyushu University

野田百美教授主要研究氢水对帕金森病治疗机制，她们小组提出氢水可以在非常低（1/20的饱和）的浓度时发挥作用，饮氢水所以能产生对脑的保护作用，主要是能刺激胃细胞释放更多饥饿素，后者可以产生神经保护作用。这也是该领域比较值得重视的一种观点和解释。

1.       Matsumoto A, Yamafuji M, Tachibana T, Nakabeppu Y, Noda M, Nakaya H. Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice. Sci Rep. 2013 Nov 20;3:3273.

2.       Fujita K, Yamafuji M, Nakabeppu Y, Noda M. Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes. Oxid Med Cell Longev. 2012;2012:324256.

3.       Noda M, Fujita K, Lee CH, Yoshioka T. The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties. Curr Pharm Des. 2011;17(22):2253-63

4.       Fujita K, Nakabeppu Y, Noda M. Therapeutic effects of hydrogen in animal models of Parkinson's disease. Parkinsons Dis. 2011;2011:307875

5.       Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. PLoS One. 2009 Sep 30;4(9):e7247