脑外科手术可以导致无法避免的脑组织损伤，手术直接损伤和损伤导致的继发氧化损伤是脑水肿形成的重要原因，本研究检测氢气是否对大鼠脑外科手术损伤的作用。

成年SD大鼠(weight 300-350g)随机分为三组，假手术组、非治疗组和呼吸(2.9%)氢气组。24小时后进行脑水含量、MPO、LPO、和神经功能检测。

结果发现手术局部脑组织水肿、神经功能损伤均显著改善。但是氧化指标未见明显改变。

结论：氢气尽管能保护脑组织损伤，降低脑水肿，提高脑功能，但是否通过抗氧化仍需要进一步研究。氢气对临床脑外科手术引起的脑组织损伤具有作用，是一种潜在的可减少医疗费用的治疗手段。

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Hydrogen is Neuroprotective against Surgically Induced Brain Injury

Jan M Eckermann, Wanqiu Chen, Vikram Jadhav, Frank PK Hsu, Austin RT Colohan, Jiping Tang and John H Zhang

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Medical Gas Research 2011, 1:7 doi:10.1186/2045-9912-1-7

Published: 18 May 2011

Abstract (provisional)

Background

Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effect of hydrogen (H2) in an established surgical brain injury (SBI) model in rats.

Material and methods

Adult male Sprague - Dawley rats (weight 300-350g) were divided into three groups to serve as sham operated, SBI without treatment, and SBI treated with H2 (2.9%). Brain water content, myeloperoxidase (MPO) assay, lipid peroxidation (LPO), and neurological function were measured at 24 hrs after SBI.

Results

SBI resulted in localized brain edema (p=<0.001). Hydrogen (2.9%) administered concurrently with surgery significantly decreased the formation of cerebral edema (p=0.028) and improved neurobehavioral testing (p=0.022). However, hydrogen treatment failed to reduce oxidative stress (LPO assay) or inflammation (MPO assay) in brain tissues.

Conclusions

Hydrogen appears to be promising as an effective, yet inexpensive way to reduce cerebral edema caused by surgical procedures. Hydrogen has the potential to improve clinical outcome, decrease hospital stay, and reduce overall cost to patients and the health care system.

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