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氢气生理盐水可治疗大鼠脊髓损伤
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氢气治疗脑缺血再灌注损伤是07年被发现的，随后人们先后证明对其他器官缺血再灌注损伤中的作用，例如在心脏、肝脏、小肠等，但仍没有关于脊髓损伤的文章，长征医院麻醉科
脊髓损伤是各类创伤中比较重要的类型，由于容易导致患者脊髓功能障碍，严重影响患者生活质量，一直是临床急救医学非常关注的课题，尽管经过长期大量的临床与基础研究，但对该疾病仍缺乏特别有效的治疗手段。最近关于炎症反应在脊髓损伤中的作用逐渐受到重视，而炎症反应中非常重要的一个因素就是氧化应激损伤，因此通过减轻氧化应激。氢气的抗氧化效应的发现使人们意识到氢气可能对炎症也具有潜在的应用价值。最近在小肠缺血，小肠、心脏和肾脏移植等研究中，发现呼吸氢气或氢气水都具有抗炎症作用。氢气对脊髓损伤后炎症是否具有对抗作用，从而发挥治疗脊髓损伤的作用，是非常值得尝试的研究课题。本研究通过制备稳定的动物模型，通过检测脊髓损伤后细胞碉亡、氧化损伤和神经营养因素等指标，初步确定，氢气具有治疗脊髓损伤的作用。尽管该研究尚需要更加深入细致的细胞学和分子机制研究，但提示氢气在脊髓损伤中具有潜在的临床应用价值。
In the present study, we examined the mechanisms of hydrogen-rich saline, a
reported therapeutic antioxidant, in the treatment of acute spinal cord
contusion injury. Male Sprague-Dawley rats were used to produce a
standardized model of contuses spinal cord injury (125 kdyn force).
Hydrogen-rich saline was injected intraperitoneally (5ml/kg) immediately, and
at 24 and 48 hours after injury. All rats were sacrificed at 72 hours after spinal
cord injury (SCI). Apoptotic cell death, oxidative stress, inflammation, level of
Brain derived neurotrophic factor (BDNF) were evaluated. In addition,
locomotor behavior was assessed using the Basso, Beattice and Bresnahan
(BBB) scale. We observed that administration of hydrogen-rich saline
decreased the number of apoptotic cells, suppressed oxidative stress, and
improved locomotor functions. Hydrogen-rich saline increased the release of
BDNF. In conclusion, hydrogen-rich saline reduced acute spinal cord contusion
injury, possibly by reduction of oxidative stress and elevation of BDNF.
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