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Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats

Abstract
Objective: Hydrogen has been reported to selectively reduce the hydroxyl radical, the most
cytotoxic of reactive oxygen species. In this study we investigated the effects of hydrogen-rich
saline on the prevention of lung injury induced by intestinal ischemia/reperfusion (I/R) in rats.
Methods: Male Sprague–Dawley rats (n=30, 200-220 g) were divided randomly into three
experimental groups: sham operated, intestinal I/R plus saline treatment (5ml/kg, i.v.), and
intestinal I/R plus hydrogen-rich saline treatment (5ml/kg, i.v.) groups. Intestinal I/R was produced
by 90 min of intestinal ischemia followed by a 4 h of reperfusion. Results: Hydrogen-rich saline
treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-κB activation
and the pro-inflammatory cytokine interleukin IL-1β and TNF-α in the lung tissues compared with
those in saline treated rat. Conclusion: Hydrogen-rich saline attenuates lung injury induced by
intestinal I/R.
Key words: Intestinal ischemia/reperfusion; Oxidative stress; Lung injury; Antioxidant;
Hydrogen-rich saline

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发表

Fig. 1. Photomicrographs of left lower lung sections from the sham group (A), saline-treated II/R group (B) and hydrogen-rich saline-treated II/R group (C) after 90 min of
intestinal ischemia followed by 4 h of reperfusion. (A) Normal histopathology, (B) the lung tissues revealed edema, alveolar hemorrhage and inflammatory cell infiltration, (C)
moderate edema, hemorrhage and inflammatory cell infiltration. Routine hematoxylin and eosin stained (200).12345

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