中国人脑库中心

中国人脑库中心（Chinese Brain Bank Center，CBBC）2005年在国家自然科学基金面上项目支持下开始筹备，2007年正式启动。截至2018，中心共收集了1800多个人脑，成为按国际标准运作的亚洲最大的人脑组织库平台。中国人脑库中心收集到的人脑按照中心制定的标准方案进行长期储存并提供给研究人员进行科学研究。多年来，我国的研究人员使用中心提供的人脑和其它组织材料已发表了几十篇高质量研究论文（如PNAS、Nature Neuroscience、Nature Communications、PLoS Genetics、PLoS Biol、Genome Res、BMC Genomics等）。2016年中心以“人脑库的建设和应用及相关技术开发”申报的科研成果获湖北省科学技术进步三等奖。

戴甲培 教授: 主任
周亦武 教授: 执行主任

孙燕 讲师: 副主任

肖芳艳： 秘书

中国最大人脑库 研究人类“留在人间的智慧”

http://www.chinadaily.com.cn/dfpd/hub/bwzg/2012-10/30/content_15857646.htm 

记者探访中国人脑库：脑组织放超低温冰箱里

https://news.qq.com/a/20120922/000038.htm 

国内规模最大人脑库：1800多个人脑用于科研(图)

https://society.huanqiu.com/article/9CaKrnJGWY9?w=280 

武汉科学家揭人为何比动物聪明 人脑能量消耗最低

http://hb.sina.com.cn/news/2016-08-27/detail-ifxvixer7323775.shtml 

中国人脑库中心提供的脑组织获得的研究成果：

1. 1. Yang F, Wang K, Zhou K, Dai B, Dai J, Liang Y, Cui M. Synthesis and bioevaluation of technetium-99 m / rhenium labeled phenylquinoxaline derivatives as Tau imaging probes. Eur J Med Chem. 2019 Sep 1; 177:291-301. doi: 10.1016/j.ejmech.2019.05.065.

2. 2. Li H, Chang H, Song X, Liu W, Li L, Wang L, Yang Y, Zhang L, Li W, Zhang Y, Zhou DS, Li X, Zhang C, Fang Y, Sun Y, Dai JP, Luo XJ, Yao YG, Xiao X, Lv L, Li M. Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder. Neuropsychopharmacology. 2019 Feb 16. doi: 10.1038/s41386-019-0346-3.

3. 3. Yang L, Yang Y, Yuan J, Sun Y, Dai J, Su B. Transcriptomic Landscape of von Economo Neurons in Human Anterior Cingulate Cortex Revealed by Microdissected-Cell RNA Sequencing. Cereb Cortex. 2019 Feb 1;29(2):838-851. doi: 10.1093/cercor/bhy286.

4. 4. Zhou K, Li Y, Peng Y, Cui X, Dai J, Cui M. Structure-Property Relationships of Polyethylene Glycol Modified Fluorophore as Near-Infrared Aβ Imaging Probes. Anal Chem. 2018 Jul 17;90(14):8576-8582. doi: 10.1021/acs.analchem.8b01712.

5. 5. Song J, Peng X, Li L, Yang F, Zhang X, Zhang J, Dai J, Cui M. Al(18)F-NODA Benzothiazole Derivatives as Imaging Agents for Cerebrovascular Amyloid in Cerebral Amyloid Angiopathy. ACS Omega. 2018 Oct 31;3(10):13089-13096. doi:10.1021/acsomega.8b01120.

6. 6. Zhao L, Chang H, Zhou DS, Cai J, Fan W, Tang W, Tang W, Li X, Liu W, Liu F, He Y, Bai Y, Sun Y, Dai J, Li L, Xiao X, Zhang C, Li M. Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population. Transl Psychiatry. 2018 Dec 7;8(1):270. doi:10.1038/s41398-018-0337-x.

7. 7. Zhang X, Hou Y, Peng C, Wang C, Wang X, Liang Z, Lu J, Chen B, Dai J, Liu B, Cui M. Oligoethyleneoxy-Modified 99mTc-Labeled β-Amyloid Imaging Probes with Improved Brain Pharmacokinetics for Single-Photon Emission Computed Tomography. J Med Chem. 2018 Feb 8;61(3):1330-1339. doi: 10.1021/acs.jmedchem.7b01834.

8. 8. Zhou K, Bai H, Feng L, Dai J, Cui M. Smart D-π-A Type Near-Infrared Aβ Probes: Effects of a Marked π Bridge on Optical and Biological Properties. Anal Chem. 2017 Sep 5;89(17):9432-9437.

9. 9. Song J, Zhang X, Zhao Y, Yang H, Zhang J, Zhang X, Dai J, Cui M. (R)- and (S)-(18)F-labeled 2-arylbenzofurans with improved pharmacokinetics as β-amyloid imaging probes. Eur J Med Chem. 2017 Jul 7;134:271-280.

10. 10. Yang Y, Wang X, Yang H, Fu H, Zhang J, Zhang X, Dai J, Zhang Z, Lin C, Guo Y, Cui M. Synthesis and Monkey-PET Study of (R)- and (S)-(18)F-Labeled 2-Arylbenzoheterocyclic Derivatives as Amyloid Probes with Distinctive in Vivo Kinetics. Mol Pharm. 2016 Nov 7;13(11):3852-3863. PubMed PMID: 27744706.

11. 11. Jia J, Zhou K, Dai J, Liu B, Cui M. 2-Arylbenzothiazoles labeled with [CpRe/(99m)Tc(CO)(3)] and evaluated as β-amyloid imaging probes. Eur J Med Chem. 2016 Nov 29;124:763-772. doi: 10.1016/j.ejmech.2016.09.001. PubMed PMID:27639367.

12. 12. Fu H, Peng C, Liang Z, Dai J, Liu B, Cui M. In vivo near-infrared and Cerenkov luminescence imaging of amyloid-β deposits in the brain: a fluorinated small molecule used for dual-modality imaging. Chem Commun (Camb). 2016 Oct 20;52(86):12745-12748. PubMed PMID: 27722543.

13. 13. Zhang X, Yu P, Yang Y, Hou Y, Peng C, Liang Z, Lu J, Chen B, Dai J, Liu B, Cui M. (99m)Tc-Labeled 2-Arylbenzothiazoles: Aβ Imaging Probes with Favorable Brain Pharmacokinetics for Single-Photon Emission Computed Tomography. Bioconjug Chem. 2016 Oct 7. [Epub ahead of print] PubMed PMID: 27668687.

14. 14. Wang Z, Wang N, Li Z, Xiao F, Dai J. Human high intelligence is involved in spectral redshift of biophotonic activities in the brain. Proc Natl Acad Sci U S 2016 Aug 2;113(31):8753-8. doi: 10.1073/pnas.1604855113. PubMed PMID: 27432962; PubMed Central PMCID: PMC4978290.

15. 15. Jia J, Song J, Dai J, Liu B, Cui M. Optically Pure Diphenoxy Derivatives as More Flexible Probes for β-Amyloid Plaques. ACS Chem Neurosci. 2016 Sep 21;7(9):1275-82. doi: 10.1021/acschemneuro.6b00155. PubMed PMID: 27337293.

16. 16. Li Z, Dai J. Biophotons Contribute to Retinal Dark Noise. Neurosci Bull. 2016 Jun;32(3):246-52. doi: 10.1007/s12264-016-0029-6. PubMed PMID: 27059222.

17. 17. Liu C, Saffen D, Schulze TG, Burmeister M, Sham PC, Yao YG, Kuo PH, Chen C, An Y, Dai J, Yue W, Li MX, Xue H, Su B,Chen L, Shi Y, Qiao M, Liu T, Xia K, Chan RC. Psychiatric genetics in China: achievements and challenges. Mol Psychiatry. 2016 Jan;21(1):4-9.

18. 18. Fu H, Tu P, Zhao L, Dai J, Liu B, Cui M. Amyloid-β Deposits Target Efficient Near-Infrared Fluorescent Probes: Synthesis, in Vitro Evaluation, and in Vivo Imaging. Anal Chem. 2016 Feb 2;88(3):1944-50.

19. 19. Chen L, Tao Y, Song F, Yuan X, Wang J, Saffen D. Evidence for genetic regulation of mRNA expression of the dosage-sensitive gene retinoic acid induced-1 (RAI1) in human brain. Sci Rep. 2016 Jan 8;6:19010.

20. 20. Zhu HX, Xue ZQ, Qiu WY, Zeng ZJ, Dai JP, Ma C, Luo XG, Yan XX. Age-related intraneuronal accumulation of  αII-spectrin breakdown product SBDP120 in the human cerebrum isenhanced in Alzheimer's disease. Exp Gerontol. 2015 Jun 4;69:43-52.

21. 21. Yang Y, Fu H, Cui M, Peng C, Liang Z, Dai J, Zhang Z, Lin C, Liu B. Preliminary evaluation of fluoro-pegylated benzyloxybenzenes for quantification of β-amyloid plaques by positron emission tomography. Eur J Med Chem. 2015 Nov 2;104:86-96.

22. 22. Fu H, Cui M, Zhao L, Tu P, Zhou K, Dai J, Liu B. Highly sensitive near-infrared fluorophores for in vivo detection of amyloid-β plaques in alzheimer's disease. J Med Chem. 2015 Sep 10;58(17):6972-83.

23. 23. Yang Y, Zhang X, Cui M, Zhang J, Guo Z, Li Y, Zhang X, Dai J, Liu B. Preliminary characterization and in vivo studies of structurally identical (18)f-and (125)i-labeled benzyloxybenzenes for PET/SPECT imaging of β-amyloid plaques. Sci Rep. 2015 Jul 14;5:12084.

24. 24. Zhou K, Fu H, Feng L, Cui M, Dai J, Liu B. The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques. Chem Commun (Camb). 2015 Jul 25;51(58):11665-8.

25. 25. Jia J, Cui M, Dai J, Liu B. 99mTc(CO)3-labeled benzothiazole derivatives preferentially bind cerebrovascular amyloid: potential use as imaging agents for cerebral amyloid angiopathy. Mol Pharm. 2015 Aug 3;12(8):2937-46.

26. Jia J, Cui M, Dai J, Liu B. 2-Phenylbenzothiazole conjugated with cyclopentadienyl tricarbonyl [CpM(CO)3] (M = Re, (99m)Tc) complexes as potential imaging probes for β-amyloid plaques. Dalton Trans. 2015 Apr 14;44(14):6406-15.

27. 26. Sun Y, Tao Y, Wang J, Saffen D. The schizophrenia/bipolar disorder candidate gene GNB1L is regulated in human temporal cortex by a cis-acting element located within the 3'-region. Neurosci Bull. 2015 Feb;31(1):43-52.

28. 27. Li Z, Cui M, Zhang J, Dai J, Zhang X, Chen P, Jia H, Liu B. Novel 1⁸F-labeled dibenzylideneacetone derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques. Eur J Med Chem. 2014 Sep 12;84:628-38.

29. 28. Yang Y, Cui M, Zhang X, Dai J, Zhang Z, Lin C, Guo Y, Liu B. Radioiodinated benzyloxybenzene derivatives: a class of flexible ligands target to β-amyloid plaques in Alzheimer's brains. J Med Chem. 2014 Jul 24;57(14):6030-42.

30. 29. Li Z, Cui M, Dai J, Wang X, Yu P, Yang Y, Jia J, Fu H, Ono M, Jia H, Saji H, Liu B. Novel cyclopentadienyl tricarbonyl complexes of (99m)Tc mimicking chalcone as potential single-photon emission computed tomography imaging probes for β-amyloid plaques in brain. J Med Chem. 2013 Jan 24;56(2):471-82.

31. 30. Hughes DA, Kircher M, He Z, Guo S, Fairbrother GL, Moreno CS, Khaitovich P, Stoneking M. Evaluating intra- and inter-individual variation in the human placental transcriptome. Genome Biol. 2015 Mar 19;16:54. doi: 10.1186/s13059-015-0627-z.

32. 31. Wei YN, Hu HY, Xie GC, Fu N, Ning ZB, Zeng R, Khaitovich P. Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging. Genome Biol. 2015 Feb 22;16:41. doi: 10.1186/s13059-015-0608-2.

33. 32. Bozek K, Wei Y, Yan Z, Liu X, Xiong J, Sugimoto M, Tomita M, Pääbo S, Sherwood CC, Hof PR, Ely JJ, Li Y, Steinhauser D, Willmitzer L, Giavalisco P, Khaitovich P. Organization and evolution of brain lipidome revealed by large-scale analysis of human, chimpanzee, macaque, and mouse tissues. Neuron. 2015 Feb 18;85(4):695-702. doi: 10.1016/j.neuron.2015.01.003. Epub 2015 Feb 5.

34. 33. Su ZD, Sheng QH, Li QR, Chi H, Jiang X, Yan Z, Fu N, He SM, Khaitovich P, Wu JR, Zeng R. De novo identification and quantification of single amino-acid variants in human brain. J Mol Cell Biol. 2014 Oct;6(5):421-33.

35. 34. Zhu M, Tao Y, He Q, Gao H, Song F, Sun YM, Li HL, Wu ZY, Saffen D. Common GSAP promoter variant contributes to Alzheimer's disease liability. Neurobiol Aging. 2014 Nov;35(11):2656.e1-7.

36. 35. Hu HY, He L, Khaitovich P. Deep sequencing reveals a novel class of bidirectional promoters associated with neuronal genes. BMC Genomics. 2014 Jun 10;15:457.

37. 36. Bozek K, Wei Y, Yan Z, Liu X, Xiong J, Sugimoto M, Tomita M, Pääbo S, Pieszek R, Sherwood CC, Hof PR, Ely JJ, Steinhauser D, Willmitzer L, Bangsbo J, Hansson O, Call J, Giavalisco P, Khaitovich P. Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. PLoS Biol. 2014 May 27;12(5):e1001871.

38. 37. He Z, Bammann H, Han D, Xie G, Khaitovich P. Conserved expression of lincRNA during human and macaque prefrontal cortex development and maturation. RNA. 2014 May 20

39. 38. Khrameeva EE, Bozek K, He L, Yan Z, Jiang X, Wei Y, Tang K, Gelfand MS, Prufer K, Kelso J, Paabo S, Giavalisco P, Lachmann M, Khaitovich P. Neanderthal ancestry drives evolution of lipid catabolism in contemporary Europeans. Nat Commun. 2014 Apr 1;5:3584. doi: 10.1038/ncomms4584.

40. 39. Zhao G, Guo S, Somel M, Khaitovich P. (2014) Evolution of human longevity uncoupled from caloric restriction mechanisms. PLoS One. 2014;9(1):e84117.

41. 40. Li Z, Bammann H, Li M, Liang H, Yan Z, Phoebe Chen YP, Zhao M, Khaitovich P. (2013) Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee, and macaque brains. RNA. 2013 Oct 23.

42. 41. Mazin P, Xiong J, Liu X, Yan Z, Zhang X, Li M, He L, Somel M, Yuan Y, Phoebe Chen YP, Li N, Hu Y, Fu N, Ning Z, Zeng R, Yang H, Chen W, Gelfand M, Khaitovich P. (2013) Widespread splicing changes in human brain development and aging. Mol Syst Biol. 2013 Jan 22;9:633. doi: 10.1038/msb.2012.67.

43. 42. Somel M, Liu X, Khaitovich P. (2013) Human brain evolution: transcripts, metabolites and their regulators. Nat Rev Neurosci. 2013 Feb;14(2):112-27. doi: 10.1038/nrn3372.

44. 43. Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H. (2013) Birth and expression evolution of mammalian microRNA genes. Genome Res. 2013 Jan;23(1):34-45. doi: 10.1101/gr.140269.112.

45. 44. Hu HY, He L, Fominykh K, Yan Z, Guo S, Zhang X, Taylor MS, Tang L, Li J, Liu J, Wang W, Yu H, Khaitovich P. (2012) Evolution of the human-specific microRNA miR-941. Nat Commun. 2012 Oct 23;3:1145. doi: 10.1038/ncomms2146.

46. 45. Weng K, Hu H, Xu AG, Khaitovich P, Somel M. (2012) Mechanisms of Dietary Response in Mice and Primates: A Role for EGR1 in Regulating the Reaction to Human-Specific Nutritional Content. PLoS One. 2012;7(8):e43915. Epub 2012 Aug 24.

47. 46. Yuan Y, Chen YP, Boyd-Kirkup J, Khaitovich P, Somel M. (2012) Accelerated aging-related transcriptome changes in the female prefrontal cortex. Aging Cell. 2012 Jul 11. doi: 10.1111/j.1474-9726.2012.00859.x.

48. 47. Khaitovich P. (2012) Layer cake: the first bite at gene expression diversity in the human brain. Genome Biol. 13(5):157

49. Khrameeva EE, Mironov AA, Fedonin GG, Khaitovich P, Gelfand MS. (2012) Spatial proximity and similarity of the epigenetic state of genome domains. PLoS One.2012;7(4):e33947. Epub 2012 Apr 4

50. 48. Liu X, Somel M, Tang L, Yan Z, Jiang X, Guo S, Yuan Y, He L, Oleksiak A, Zhang Y, Li N, Hu Y, Chen W, Qiu Z, Pääbo S, Khaitovich P. (2012) Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res, (2012-02-02)

51. 49. Somel M, Liu X, Tang L, Yan Z, Hu H, Guo S, Jiang X, Zhang X, Xu G, Xie G, Li N, Hu Y, Chen W, Pääbo S, Khaitovich P. (2011) MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates. PLoS Biol. 9(12): e1001214.

52. 50. Hu HY, Guo S, Jiang X, Yan Z, Fu N, Zhang X, Menzel C, Liang H, Yang H, Zhao M, Zeng R, Chen W, Pääbo S, Khaitovich P. (2011) MicroRNA Expression and Regulation in Human, Chimpanzee, and Macaque Brains. PLoS Genetics. 7(10): e1002327.

53. 51. Yuan Y, Chen YP, Ni S, Xu AG, Tang L, Vingron M, Somel M, Khaitovich P. (2011) Development and application of a modified dynamic time warping algorithm (DTW-S) to analyses of primate brain expresion time series. BMC Bioinformatics. 12(1):347

54. 52. Yan Z, Hu H, Jiang X, Maierhofer V, Neb E, He L, Hu Y, Hu H, Li N, Chen W and Khaitovich P. (2011) Widespread expression of piRNA-like molecules in somatic tissues. Nucleic Acids Research. May 5.

55. 53. Fu X, Giavalisco P, Liu X, Catchpole G, Fu N, Ning ZB, Guo S, Yan Z, Somel M, Pääbo S, Zeng R, Willmitzer L, Khaitovich P. (2011) Rapid metabolic evolution in human prefrontal cortex. Proc Natl Acad Sci U S A. Mar 28.

56. 54. Wang C, Liu F, Liu YY, Zhao CH, You Y, Wang L, Zhang J, Wei B, Ma T, Zhang Q, Zhang Y, Chen R, Song H, Yang Z. Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain. Cell Res. 2011 Nov;21(11):1534-50.

57. 55. Ma T, Wang C, Wang L, Zhou X, Tian M, Zhang Q, Zhang Y, Li J, Liu Z, Cai Y, Liu F, You Y, Chen C, Campbell K, Song H, Ma L, Rubenstein JL, Yang Z. ubcortical origins of human and monkey neocortical interneurons. Nat Neurosci. 2013 Nov;16(11):1588-97.

58. 56. Xu X, Wang H, Zhu M, Sun Y, Tao Y, He Q, Wang J, Chen L, Saffen D. Next-generation DNA sequencing-based assay for measuring allelic expression imbalance (AEI) of candidate neuropsychiatric disorder genes in human brain. BMC Genomics. 2011 Oct 20;12:518.

59. 57. Somel M, Guo S, Fu N, Yan Z, Hu HY, Xu Y, Yuan Y, Ning Z, Hu Y, Menzel C, Hu H, Lachmann M, Zeng R, Chen W, Khaitovich P. (2010) MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res20(9):1207-18.

60. 58. Xu AG, He L, Li Z, Xu Y, Li M, Fu X, Yan Z, Yuan Y, Menzel C, Li N, Somel M, Hu H, Chen W, Pääbo S, Khaitovich P. (2010) Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-Seq. PLoS Comput Biol1;6:e1000843.

61. 59. Shao NY, Hu HY, Yan Z, Xu Y, Hu H, Menzel C, Li N, Chen W, Khaitovich P. (2010) Comprehensive survey of human brain microRNA by deep sequencing. BMC Genomics11:409.