李英和吴毓林教授最新文章
2010-12-13 13:28
阅读：5061
标签：青蒿素, 523, 中医药
A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu
Authors:
Frontiers of Chemistry in China
Volume 5, Issue 4 (2010). Pages: 357-422
DOI: 10.1007/s11458-010-0214-5
http://journal.hep.com.cn/webpub/cipub/articledetail?articleid=2E7F80B0-E177-11DF-A3A1-9941DC162EC7&journalid=5&jyear=2010&issue=4&type=
A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu
Authors:
1
1. Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
2. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Abstract:
Qinghaosu (QHS) and its derivatives are a new generation of antimalarial drugs characterized by fast action, high efficacy, and good tolerance. This feature article states the discovery of QHS from traditional Chinese medicine qinghao (Artemisia annua L.) and reviews the progress during the past four decades in the research of phytochemistry of A. annua, chemical reactions and biotransformation of QHS, chemical synthesis and biosynthesis of QHS, synthesis and antimalarial activity of QHS derivatives and analogs, pharmacological studies, clinical application, and the antimalarial mechanism. Undoubtedly, QHS is an example of the value of traditional Chinese medicine in modern medicinal research.
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