Science Blog of Dr. Yuan分享 This blog is mainly on Molecular molecular modelling and simulations


Designing Safer Analgesics via u-Opioid Receptor Pathways

已有 1801 次阅读 2017-9-21 19:16 |个人分类:科研笔记|系统分类:科研笔记

HCS Chan, D McCarthy, J Li, K Palczewski, S Yuan*. Trends in Pharmacological Science (2017)

Pain is both a major clinical and economic problem, affecting more people than diabetes, heart disease, and cancer combined. While a variety of prescribed or over-the-counter (OTC) medications are available for pain management, opioid medications, especially those acting on the m-opioid receptor (mOR) and related pathways, have [485_TD$DIFF]proven to be the most effective, despite some serious side effects including respiration depression, pruritus, dependence, and con- stipation. It is therefore imperative that both academia and industry develop novel mOR analgesics which retain their opioid analgesic properties but with fewer or no adverse effects. In this review we outline recent progress towards the discovery of safer opioid analgesics.

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