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MCE 国际站:Gentamicin (sulfate)
中文名:硫酸庆大霉素
CAS:1405-41-0
品牌:MedChemExpress (MCE)
存储条件:4°C, sealed storage, away from moisture
生物活性:硫酸庆大霉素是一种具有口服活性的氨基糖苷类抗生素,可抑制革兰氏阳性和革兰氏阴性细菌的生长,并抑制组织培养中的多种支原体菌株。硫酸庆大霉素抑制 DNase I,IC50 为 0.57 mM[1][2][3][4]。 IC50 和目标:IC50:0.57 mM(DNase I)[1]
体外:庆大霉素是一种比联合青霉素-链霉素更有效的体外细菌抑制剂,对组织培养单层无毒,并且不抑制病毒复制[2]。庆大霉素已成功用作商业真菌学培养基中的添加剂以抑制细菌的生长,并已被证明对更广泛的生物体具有杀菌作用(铜绿假单胞菌、变形杆菌属。 i>, and Streptococcus faecalis) 优于青霉素和链霉素[2]。庆大霉素不干扰组织中某些埃可病毒和脊髓灰质炎病毒产生的细胞病变效应培养物,对恒河猴肾脏、HeLa 和人羊膜细胞无毒,并且在高压灭菌温度下稳定[2]。庆大霉素由小单孢菌属[3]的各种物种产生。RNA[3]。
体内:庆大霉素(口服和注射剂型)在小鼠感染模型[3]中证实对鼠疫耶尔森氏菌具有有效的抗菌活性。庆大霉素(0.27 g/kg)显示小鼠异物上的细菌显着减少[4]。
动物体内实验:小鼠:用甲氧西林、庆大霉素、甲氧西林和庆大霉素治疗受细菌攻击的小鼠,或不使用抗生素。治疗每天 3 次,持续 3 天。甲氧西林每次剂量为每只小鼠75毫克(3克/千克体重),庆大霉素剂量为每只小鼠0.75毫克(0.03克/千克体重)。抗生素以 0.1 或 0.5 mL 生理盐水皮下注射。处死小鼠并收集血清和抽吸样品[4]。
热销产品:Tideglusib | Traumatic Acid | 7-Chlorokynurenic acid | Quiflapon | GNE-0946 | DBCO-PEG12-NHS ester | Polatuzumab vedotin | Hirudin, Poecilobdella viridis (P. pastoris) | Betamethasone | Protocatechualdehyde
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Xu W, et al. A rapid and sensitive method for kinetic study and activity assay of DNase I in vitro based on a GO-quenched hairpin probe. Anal Bioanal Chem. 2016 May;408(14):3801-9.
[2]. Rudin A, et al. Antibacterial activity of gentamicin sulfate in tissue culture. Appl Microbiol. 1970 Dec;20(6):989-90.
[3]. Kumar CG, et al. Microbial biosynthesis and applications of gentamicin: a critical appraisal.
[4]. Espersen F, et al. Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreignbody infection. Antimicrob Agents Chemother. 1994 Sep;38(9):2047-53.
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