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MCE 国际站:Prednisolone
中文名:泼尼松龙
CAS:50-24-8
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:泼尼松龙是一种有效的口服活性皮质类固醇和糖皮质激素。泼尼松龙的抗炎活性是氢化可的松的四倍左右,同时减少盐和水潴留。泼尼松龙可用于眼部、抗炎研究[1][2]。
体外:泼尼松龙(0.002-10 μg/mL;3 天)抑制人白细胞有丝分裂[4]。
体内:泼尼松龙(5 毫克/千克/天;口服;每周 6 天,持续 72 周)显着预防小鼠因肾病死亡[3]。
热销产品:BIRT 377 | Methionine | Acephate | BX517 | Chrysophanein | Luminol | Ketoprofen | Phospho-EGFR (Tyr1068) Antibody | dBET23 | SPP
研究领域:Immunology/Inflammation | Vitamin D Related/Nuclear Receptor | Metabolic Enzyme/Protease
作用靶点:Glucocorticoid Receptor | Endogenous Metabolite
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Prednisolone. J Am Pharm Assoc. 1976;16(3):143-146.
[2]. Musson DG, et al. Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions. J Chromatogr. 1991;565(1-2):89-102.
[3]. Hahn B H, et al. Comparison of therapeutic and immunosuppressive effects of azathioprine, prednisolone and combined therapy in nzp/nzw mice. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 1973, 16(2): 163-170.
[4]. NOWELL PC. Inhibition of human leukocyte mitosis by prednisolone in vitro. Cancer Res. 1961 Dec;21:1518-21.
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