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MCE 国际站:Bilirubin
中文名:胆红素
CAS:635-65-4
品牌:MedChemExpress (MCE)
存储条件:-20°C, protect from light
生物活性:胆红素是血红素分解代谢的黄色分解产物[1]。胆红素具有抗氧化和抗突变作用[2]。
体外:未结合的胆红素以浓度依赖性方式抑制 ADAMTS13 对 F485-rVWF73-H、D633-rVWF73-H 和 GST-rVWF71-11K 的裂解,半数最大抑制浓度 (IC50)分别为 ~13 μM、~70 μM 和 ~17 μM。在变性条件下,未结合的胆红素还会剂量依赖性地抑制 ADAMTS13 对多聚体 VWF 的切割[1]。胆红素在体外具有抗氧化和抗突变作用[2]。
热销产品:4-Hydroxyatomoxetine | Tafasitamab | PSI | Dienogest | Curcumenol | Oxyphenbutazone | HB-EGF, Mouse | Lecirelin | Platelet Factor 4 (58-70), human | Kojic acid
研究领域:Metabolic Enzyme/Protease
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Lu RN, et al. Unconjugated Bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease. J Thromb Haemost. 2015 Jun;13(6):1064-72.
[2]. Mölzer C, et al. Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide. J Nat Prod. 2013 Oct 25;76(10):1958-65.
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