JAK2 JH2 Tracer

CAS：2101955-00-2

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性： JAK2 JH2 Tracer 是 JAK2 JH2 结构域的荧光探针，K_d 为 0.2 μM。

体外：JAK2 JH2 Tracer shows a minimum tracer concentration that retains a satisfactory signal-to-noise ratio is found to be 1.5 pM[1].?JAK2 JH2 Tracer shows a dissociation constants near 0.2 μM[1].?JAK2 JH2 Tracer shows a high binding affinity with a Kd value of 0.2 μM for JAK2 JH2 domain by saturation experiments[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies[2].?Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献：[1]. Newton AS, et al. JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Med Chem Lett. 2017 May 17;8(6):614-617.[2]. Ihle JN, Gilliland DG. Jak2: normal function and role in hematopoietic disorders. Curr Opin Genet Dev. 2007 Feb;17(1):8-14.