Utomilumab

MCE 国际站：Utomilumab

CAS：1417318-27-4

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：Utomilumab (PF 05082566) 是 T 细胞共刺激受体 4-1BB/CD137 的全人 IgG2 mAb 激动剂。优托木单抗可用于复发/难治性滤泡性淋巴瘤（FL）和其他CD20⁺非霍奇金淋巴瘤（NHL）^{[1][2]的研究}。

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研究领域：Apoptosis

作用靶点：TNF Receptor

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参考文献：[1]. Anthony W Tolcher, et al. Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors. Clin Cancer Res. 2017 Sep 15;23(18):5349-5357.

[2]. Ajay K Gopal, et al. First-in-Human Study of Utomilumab, a 4-1BB/CD137 Agonist, in Combination with Rituximab in Patients with Follicular and Other CD20⁺ Non-Hodgkin Lymphomas. Clin Cancer Res. 2020 Jun 1;26(11):2524-2534.