Polyphyllin VI | 重楼皂苷VI

MCE 国际站：Polyphyllin VI

中文名：重楼皂苷VI

CAS：55916-51-3

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Polyphyllin VI 是一种活性皂苷，具有抗癌活性。 Polyphyllin VI 诱导 G2/M 细胞周期停滞并触发细胞凋亡^[1][2]。 Polyphyllin VI 在非小细胞肺癌中通过诱导 ROS/NF-κB/NLRP3/GSDMD 信号轴诱导 caspase-1 介导的细胞焦亡^[3]。

体外：Polyphyllin VI (0-16 μM；48 小时) 以剂量依赖性方式显着降低 A549、NCI-H1299 和 HepaRG 细胞的活力[1][2]。 Polyphyllin VI (0.5-2 μM-1 μM；24 小时) 以剂量依赖性方式显着增加 A549 和 NCI-H1299 细胞处于 G2/M 期的百分比[1]。 Polyphyllin VI (0-12 μM-1 μM；24 小时) 将 HepaRG 细胞阻滞于 S 期[2]。 Polyphyllin VI (0-6 μM-1 μM；24 小时) 可激活 NLRP3 炎症小体[3]。 Polyphyllin VI (0-6 μM-1 μM；24 小时) 通过 ROS/NF-κB 途径诱导 A549 和 NCI-H1299 细胞焦亡 (pyroptosis)[3] 。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Polyphyllin VI (2-4 mg/kg；腹腔注射；每周 5 次，持续 4 周) 抑制肺癌肿瘤异种移植物的生长[1]。 Polyphyllin VI (2.5-10 mg/kg；腹腔注射；连续 10 天) 在携带 A549 肿瘤的裸鼠中激活 NLRP3 炎性小体[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: A549 tumor xenografts subcutaneously inoculated into the right flank of the nude mice[1] Dosage: 2 mg/kg, 3 mg/kg, 4 mg/kg Administration: Intraperitoneal Injection (i.p.) Result: Resulted the reduction of tumor volume to 25.63%, 41.71%, and 40.41%, respectively, after 2 mg/kg, 3 mg/kg and 4 mg/kg treatment. Animal Model: A549 tumor xenografts subcutaneously inoculated into the right flank of the nude mice[3] Dosage: 2.5 mg/kg, 5 mg/kg, 10 mg/kg Administration: Intraperitoneal Injection (i.p.) Result: Showed the expression of NLRP3, caspase-1, IL-1β and GSDMD was increasing in a dose manner.

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研究领域：Apoptosis  |  Immunology/Inflammation

作用靶点：Apoptosis  |  Pyroptosis

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参考文献：[1]. Lin Z, et al. Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with Apoptosis In Vitro and In Vivo. Phytother Res. 2015 Oct;29(10):1568-76.

[2]. Liu Y, et al. Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway. Toxins (Basel). 2018 May 15;10(5). pii: E201.

[3]. Jin-Feng Teng, et al. Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer. Cancers (Basel). 2020 Jan 13;12(1):193.