MCE 国际站：Fenoterol (hydrobromide)
中文名：非诺特罗氢溴酸盐
CAS：1944-12-3
品牌：MedChemExpress (MCE)
存储条件：4°C, sealed storage, away from moisture
生物活性：Fenoterol hydrobromide (Th-1165a) 是一种拟交感神经药，是一种具有选择性和口服活性的 β2-adrenoceptor 激动剂。氢溴酸非诺特罗是一种有效的支气管扩张剂，可用于哮喘、支气管炎等阻塞性气道疾病相关的支气管痉挛研究[1][2]。
体外：Fenoterol（1 μM；预孵育 30 分钟）处理可降低 AICAR 诱导的 AMPK 活化、NF-κB 活化和 TNF-α 释放，还显着下调 AMPK[2] 升高的磷酸化水平。非诺特罗抑制脂多糖 (LPS) 诱导的 THP-1 细胞中 AMPK 活化和炎性细胞因子的产生[2]。非诺特罗还是一种有效的外泌体生物发生和/或分泌激活剂在 PC 细胞中[4]。
体内：非诺特罗（0.7 mg/kg；腹膜内注射；每天两次；持续 3 周）治疗可抑制慢性治疗期间的机械异常性疼痛[3]。
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研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Adrenergic Receptor
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参考文献：[1]. Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161.[2]. R C Heel, et al. Fenoterol: a review of its pharmacological properties and therapeutic efficacy in asthma. Drugs. 1978 Jan;15(1):3-32.[3]. Wei Wang, et al. Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK and NF-κB activation in AICAR-induced THP-1 cells. Biomed Pharmacother. 2016 Dec;84:185-190.[4]. Nada Choucair-Jaafar, et al. Beta2-adrenoceptor agonists alleviate neuropathic allodynia in mice after chronic treatment. Br J Pharmacol. 2009 Dec;158(7):1683-94.
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